Journal of Capital Medical University ›› 2007, Vol. 28 ›› Issue (1): 61-63.

• 基础研究 • Previous Articles     Next Articles

Study on Thiencynonate by Electron Ionization and Electron Spray Ionization Mass Spectrometry

Xu Yanxia1, Wang Lijuan1, Xue Ming1, Ruan Jinxiu2, Zhang Zhenqing2, Liu Keliang2   

  1. 1. Department of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University;2. Institute of Pharmacology and Toxicology, The Academy of Military Medical Science
  • Received:2005-12-06 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24

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Abstract: Objective Thiencynonate(TC) is a novel compound which is similar to anti-cholinergic drug developed by Institute of Pharmacology and Toxicology, used for the prevention and treatment of motion sickness or other disease caused by imbalance of function under movement stimulation and the pesticides poison of organic phosphorus. Methods For further study on it, the mass spectrometry techniques of electron ionization mass spectrometry(EI-MS) and electron spray ionization mass spectrometry(ESI-MS) were used for the elucidations of the structure and fragmentation pathway of TC. Results The results shows the molecular ion peak m/z 364[M+H]+, m/z156, were detected by ESI-MS; m/z363[M]+ and m/z138,m/z181 and m/z154, m/z221 were detected by EI-MS. Further more, the fragmentation pathway of TC was also explained. Conclusion The results provided a valuable information for the investigation and development of drugs similar to TC.

Key words: mass spectrometry, thiencynonate, electron ionization mass spectrometry, electron spray ionization mass spectrometry

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