Abstract:

Objective To determine the effect of intravenous injection of midazolam on SNAP index.Methods Ten post transsphenoidal hypophysectomy patients were enrolled in this study. All patients complained of sleeping difficult, midazolam was injected intravenously with a single bolus dose of 0.1 mg/kg. The SNAP index, Ramsay scale and Richmond Agitation and Sedation Scale(RASS) were monitored and documented before medication, and 1, 5, 15, 30, 45, 60, 90, 120 and 180 after medication. The SNAP index was compared at different time points, and was found to be correlated with the Ramsay scale or RASS.Results The baseline SNAP index was 89±6. After intravenous injection of midazolam, the SNAP index declined gradually and reached the lowest level(66±10) at 30 min after medication. After that, It rose gradually to the baseline level. The SNAP indices at 5 min to 90 min after medication were lower than the baseline level significantly(P<0.05). The SNAP index correlated significantly with the Ramsay scale and RASS, with respective Spearman correlation coefficient of-0.776 and 0.741(P<0.05).Conclusion The results of the present study indicats that the SNAP index correlates well the subjective evaluation and it might be a feasible method to monitor the depth of sedation after intravenous injection of midazolam.

Key words: sedation, SNAP index, midazolam