Determination of Plasma Levels of Tryptophan in Patients with Chronic Fatigue Syndrome

Journal of Capital Medical University ›› 2008, Vol. 29 ›› Issue (4): 483-486.

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Determination of Plasma Levels of Tryptophan in Patients with Chronic Fatigue Syndrome

Liu Zhandong¹, Wang Dexin¹, Zhang Ning², Li Ren², Chen Jun¹, Zhang Yongbo¹, Zhao Yaming¹, Xue Qiming¹

1. Department of Neurology, Beijing Friendship Hospital, Capital Medical University;2. Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University

Received:2007-09-12 Revised:1900-01-01 Online:2008-08-24 Published:2008-08-24

Abstract

Abstract: Objective To determine the changes in tryptophan levels in the chronic fatigue syndrome(CFS) patients.Methods The levels of tryptophan in the plasma of CFS patients were determined by HPLC.The patients and healthy persons were selected according to the CDC criteria.Results The levels of tryptophan in CFS(32.03±5.33)μmol/L increased significantly when compared those in controls(22.49±4.26)μmol/L.Conclusion Serotonergic dysfunction that initially came from the metabolitic disturbance of trytophan in the plasma might be one of the pathogenetic factors for CFS.

Key words: chronic fatigue syndrome, tryptophan, 5-Hydroxytryptamine, pathogenesis

CLC Number:

R749.7⁺1

Liu Zhandong;Wang Dexin;Zhang Ning;Li Ren;Chen Jun;Zhang Yongbo;Zhao Yaming;Xue Qiming. Determination of Plasma Levels of Tryptophan in Patients with Chronic Fatigue Syndrome[J]. Journal of Capital Medical University, 2008, 29(4): 483-486.

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Determination of Plasma Levels of Tryptophan in Patients with Chronic Fatigue Syndrome

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