Relationship of Estrogen Receptor β Gene Polymorphisms with Leiomyoma of the Uterus in Han Population

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (5): 660-663.

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Relationship of Estrogen Receptor β Gene Polymorphisms with Leiomyoma of the Uterus in Han Population

WANG Jia-yin¹, ZHANG Hai-zhen², GUAN Yun-qian¹, XIE Feng^2*

1. Department of Cell Therapy，Xuanwu Hospital, Capital Medical University; 2. Department of Gynecology and Obstetrics, Xuanwu Hospital, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2010-10-21 Published:2010-10-21
Contact: XIE Feng

Abstract

Abstract:

Objective The present study was designed to investigate the possible association between estrogen receptor(ER) β gene polymorphisms and leiomyoma in a Chinese(Han) population. Methods The distribution of the ERβ gene polymorphisms were examined in 285 Chinese(Han) females: 92 patients and 193 healthy controls. Genomic DNA was obtained from whole blood. ERβ gene polymorphisms were assessed by the method of polymerase chain reactionrestriction fragment-length polymorphism(PCR-RFLP). Results No significant differences between the leiomyoma patients and the controls in the frequencies of the polymorphisms in the ERβ gene were found in the subjects. Conclusion The RsaI and AluI polymorphisms of the ERβ gene were not associated with the establishment of leiomyoma of the uterus in the Chinese(Han) population.

Key words: leiomyoma of uterus, gene polymorphism, estrogen receptor &beta

CLC Number:

R 71

WANG Jia-yin;ZHANG Hai-zhen;GUAN Yun-qian;XIE Feng. Relationship of Estrogen Receptor β Gene Polymorphisms with Leiomyoma of the Uterus in Han Population[J]. Journal of Capital Medical University, 2010, 31(5): 660-663.

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Relationship of Estrogen Receptor β Gene Polymorphisms with Leiomyoma of the Uterus in Han Population

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