Research progresses in the safety of cryopreserved ovarian tissue transplantation

doi:10.3969/j.issn.1006-7795.2021.04.001

Abstract

Abstract: Ovarian tissue cryopreservation and transplantation is an established fertility preservation technique. In some types of cancer, however there may be malignant cells in the frozen ovarian tissue, so ovarian tissue transplantation is not recommended for the patient who has recovered from the disease. In order to restore the fertility of these patients, there are two main strategies: transplantable artificial ovaries, to simulate the natural organs of the ovary and isolated follicles matured in vitro into fertilizable oocytes. This article mainly reviewed the research progresses in the safety of cryopreserved ovarian tissue transplantation and the new methods to avoid disease recurrence caused by ovarian tissue transplantation with high risk of carrying malignant cells.

Key words: ovarian tissue cryopreservation, ovarian tissue transplantation, fertility preservation, safety of transplantation, artifical ovary, preantral follicles, in vitro culture

CLC Number:

R711.75

Cheng Jiaojiao, Ruan Xiangyan, Du Juan, Jin Fengyu, Li Yanglu, Gu Muqing. Research progresses in the safety of cryopreserved ovarian tissue transplantation[J]. Journal of Capital Medical University, 2021, 42(4): 505-510.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.04.001

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I4/505

References

[1] Donnez J, Dolmans M M. Fertility preservation in women[J]. Nat Rev Endocrinol, 2013,9(12):735-749.
[2] Donnez J, Dolmans M M. Fertility Preservation in Women[J]. N Engl J Med, 2017,377(17):1657-1665.
[3] ASRM. Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion[J]. Fertil Steril, 2019,112(6):1022-1033.
[4] Bockstaele L, Boulenouar S, Van Den Steen G, et al. Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation[J]. Fertil Steril, 2015,104(2):410-417.
[5] Dolmans M M, Donnez J, Cacciottola L. Fertility preservation: the challenge of freezing and transplanting ovarian tissue[J]. Trends Mol Med, 2020, S1471-4914(20)30286-0.
[6] Shapira M, Dolmans M M, Silber S, et al. Evaluation of ovarian tissue transplantation: results from three clinical centers[J]. Fertil Steril, 2020,114(2):388-397.
[7] Dolmans M M, Masciangelo R. Risk of transplanting malignant cells in cryopreserved ovarian tissue[J]. Minerva Ginecol, 2018,70(4):436-443.
[8] Bastings L, Beerendonk C C, Westphal J R, et al. Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review[J]. Hum Reprod Update, 2013,19(5):483-506.
[9] Dolmans M M. Safety of ovarian autotransplantation[J]. Blood, 2012,120(22):4275-4276.
[10] Shapira M, Raanani H, Barshack I, et al. First delivery in a leukemia survivor after transplantation of cryopreserved ovarian tissue, evaluated for leukemia cells contamination[J]. Fertil Steril, 2018,109(1):48-53.
[11] Sonmezer M, Ozkavukcu S, Sukur Y E, et al. First pregnancy and live birth in Turkey following frozen-thawed ovarian tissue transplantation in a patient with acute lymphoblastic leukemia who underwent cord blood transplantation[J]. J Assist Reprod Genet, 2020,37(8):2033-2043.
[12] Peek R, Bastings L, Westphal J R, et al. A preliminary study on a new model system to evaluate tumour-detection and tumour-purging protocols in ovarian cortex tissue intended for fertility preservation[J]. Hum Reprod, 2015,30(4):870-876.
[13] Telfer E E. Fertility preservation: Progress and prospects for developing human immature oocytes in vitro[J]. Reproduction, 2019,158(5):F45-F54.
[14] Gandolfi F, Ghiringhelli M, Brevini T. Bioengineering the ovary to preserve and reestablish female fertility[J]. Anim Reprod, 2020,16(1):45-51.
[15] Chiti M C, Donnez J, Amorim C A, et al. From isolation of human ovarian follicles to the artificial ovary: tips and tricks[J]. Minerva Ginecol, 2018,70(4):444-455.
[16] Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021,71(3):209-249.
[17] Ruan X. Chinese Society of Gynecological Endocrinology affiliated to the International Society of Gynecological Endocrinology Guideline for Ovarian Tissue Cryopreservation and Transplantation[J]. Gynecol Endocrinol, 2018,34(12):1005-1010.
[18] 国际妇科内分泌学会中国妇科内分泌学分会及共识专家. 卵巢组织冻存与移植中国专家共识[J]. 中国临床医生杂志, 2018,46(4):496-500.
[19] Donnez J, Dolmans M M, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue[J]. Lancet, 2004,364(9443):1405-1410.
[20] Meirow D, Levron J, Eldar-Geva T, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy[J]. N Engl J Med, 2005,353(3):318-321.
[21] 阮祥燕, 杜娟, 卢丹, 等. 中国自体卵巢组织冻存移植后成功妊娠首例报道_阮祥燕[J]. 中国临床医生杂志, 2021,49(3):375-378.
[22] Armstrong A G, Kimler B F, Smith B M, et al. Ovarian tissue cryopreservation in young females through the Oncofertility Consortium's National Physicians Cooperative[J]. Future Oncol, 2018,14(4):363-378.
[23] Gellert S E, Pors S E, Kristensen S G, et al. Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort[J]. J Assist Reprod Genet, 2018,35(4):561-570.
[24] Diaz-Garcia C, Herraiz S, Such E, et al. Dexamethasone does not prevent malignant cell reintroduction in leukemia patients undergoing ovarian transplant: risk assessment of leukemic cell transmission by a xenograft model[J]. Hum Reprod, 2019,34(8):1485-1493.
[25] Salama M, Anazodo A, Woodruff T K. Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach[J]. Ann Oncol, 2019,30(11):1760-1775.
[26] Chevillon F, Clappier E, Arfeuille C, et al. Minimal residual disease quantification in ovarian tissue collected in patients in complete remission of acute leukemia[J]. Blood, 2021,137(12):1697-1701.
[27] Poirot C, Fortin A, Dhedin N, et al. Post-transplant outcome of ovarian tissue cryopreserved after chemotherapy in hematologic malignancies[J]. Haematologica, 2019,104(8):e360-e363.
[28] Jahnukainen K, Tinkanen H, Wikstrom A, et al. Bone marrow remission status predicts leukemia contamination in ovarian biopsies collected for fertility preservation[J]. Leukemia, 2013,27(5):1183-1185.
[29] Telfer E E, Andersen C Y. In vitro growth and maturation of primordial follicles and immature oocytes[J]. Fertil Steril, 2021,115(5):1116-1125.
[30] Chen J, Todorov P, Isachenko E, et al. Construction and cryopreservation of an artificial ovary in cancer patients as an element of cancer therapy and a promising approach to fertility restoration[J]. Hum Fertil (Camb), 2021:1-21.
[31] Mouloungui E, Zver T, Roux C, et al. A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications[J]. J Ovarian Res, 2018,11(1):4.
[32] Soares M, Sahrari K, Amorim C A, et al. Evaluation of a human ovarian follicle isolation technique to obtain disease-free follicle suspensions before safely grafting to cancer patients[J]. Fertil Steril, 2015,104(3):672-680.
[33] Soares M, Saussoy P, Maskens M, et al. Eliminating malignant cells from cryopreserved ovarian tissue is possible in leukaemia patients[J]. Br J Haematol, 2017,178(2):231-239.
[34] Soares M, Sahrari K, Chiti M C, et al. The best source of isolated stromal cells for the artificial ovary: medulla or cortex, cryopreserved or fresh?[J]. Hum Reprod, 2015,30(7):1589-1598.
[35] Heeren A M, van Iperen L, Klootwijk D B, et al. Development of the follicular basement membrane during human gametogenesis and early folliculogenesis[J]. BMC Dev Biol, 2015,15:4.
[36] Irving-Rodgers H F, Morris S, Collett R A, et al. Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes[J]. Hum Reprod, 2009,24(4):936-944.
[37] Dong F L, Ma L, Shi S L, et al. An research on the isolation methods of frozen-thawed human ovarian preantral follicles[J]. Int J Clin Exp Med, 2014,7(8):2298-2303.
[38] Chiti M C, Dolmans M M, Hobeika M, et al. A modified and tailored human follicle isolation procedure improves follicle recovery and survival[J]. J Ovarian Res, 2017,10(1):71.
[39] Paulini F, Vilela J M, Chiti M C, et al. Survival and growth of human preantral follicles after cryopreservation of ovarian tissue, follicle isolation and short-term xenografting[J]. Reprod Biomed Online, 2016,33(3):425-432.
[40] Dath C, Dethy A, Van Langendonckt A, et al. Endothelial cells are essential for ovarian stromal tissue restructuring after xenotransplantation of isolated ovarian stromal cells[J]. Hum Reprod, 2011,26(6):1431-1439.
[41] Nikniaz H, Zandieh Z, Nouri M, et al. Comparing various protocols of human and bovine ovarian tissue decellularization to prepare extracellular matrix-alginate scaffold for better follicle development in vitro[J]. BMC Biotechnol, 2021,21(1):8.
[42] Chiti M C, Dolmans M M, Mortiaux L, et al. A novel fibrin-based artificial ovary prototype resembling human ovarian tissue in terms of architecture and rigidity[J]. J Assist Reprod Genet, 2018,35(1):41-48.
[43] Cho E, Kim Y Y, Noh K, et al. A new possibility in fertility preservation: The artificial ovary[J]. J Tissue Eng Regen Med, 2019,13(8):1294-1315.
[44] Laronda M M, Rutz A L, Xiao S, et al. A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice[J]. Nat Commun, 2017,8:15261.
[45] Delattre S, Segers I, Van Moer E, et al. Combining fertility preservation procedures to spread the eggs across different baskets: a feasibility study[J]. Hum Reprod, 2020,35(11):2524-2536.
[46] O'Brien M J, Pendola J K, Eppig J J. A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence[J]. Biol Reprod, 2003,68(5):1682-1686.
[47] Grynberg M, Mayeur L B A, Hesters L, et al. First birth achieved after fertility preservation using vitrification of in vitro matured oocytes in a woman with breast cancer[J]. Ann Oncol, 2020,31(4):541-542.
[48] Cha K Y, Koo J J, Ko J J, et al. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program[J]. Fertil Steril, 1991,55(1):109-113.
[49] McLaughlin M, Albertini D F, Wallace W, et al. Metaphase II oocytes from human unilaminar follicles grown in a multi-step culture system[J]. Mol Hum Reprod, 2018,24(3):135-142.
[50] Anderson R A, McLaughlin M, Wallace W H, et al. The immature human ovary shows loss of abnormal follicles and increasing follicle developmental competence through childhood and adolescence[J]. Hum Reprod, 2014,29(1):97-106.