Electroacupuncture selectively regulates the expression of c-Fos in the dorsal striatum of Parkinsonian mice

doi:10.3969/j.issn.1006-7795.2021.06.014

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (6): 986-992.doi: 10.3969/j.issn.1006-7795.2021.06.014

• Basic Research • Previous Articles Next Articles

Electroacupuncture selectively regulates the expression of c-Fos in the dorsal striatum of Parkinsonian mice

Su Wenting¹, Yu Jianan², Jia Jun³, Wang Xiaomin^2,3*

1. Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China;
2. Department of Neurobiology,School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China;
3. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Received:2021-07-16 Online:2021-12-21 Published:2021-12-17
Contact: * E-mail: xmwang@ccmu.edu.cn
Supported by:
National Natural Science Foundation of China (81704151,81473770),Scientific Research Common Program of Beijing Municipal Commission of Education (KM201710025014).

Abstract

Abstract: Objective To observe the selective regulation of electroacupuncture (EA) on the expression of proto oncogene protein (c-Fos) in the striatum of Parkinsonian mice, so as to explore the potential mechanism of EA in the treatment of Parkinson's disease (PD). Methods PD model mice with right side injury by 6-hydroxydopamine (6-OHDA) were made. The mice were divided into Sham, Sham+EA, Model and Model + EA groups. The “Zusanli” and “Sanyinjiao” acupoints on both sides of the lower limbs of mice were used as the stimulation sites. 100 Hz EA was applied for 30 minutes, and the c-Fos protein expression in the dorsal and ventral striatum and cingulate cortex were detected by immunohistochemistry later. Results Compared with the Sham group, the expression of c-Fos in the right dorsal side of the Model mice was significantly lower (P<0.001), and EA stimulation increased the expression of c-Fos in the right dorsal and ventral side of the Model group (P<0.05). In the cingulate cortex, there was no significant difference in the expression of c-Fos among these groups, and EA had no obvious regulatory effect. Conclusion EA can specifically activate the activity of neurons in the dorsal striatum on the injured side of parkinsonian mice.

Key words: electroacupuncture, Parkinson's disease, striatum, c-Fos expression

CLC Number:

R245.3

Su Wenting, Yu Jianan, Jia Jun, Wang Xiaomin. Electroacupuncture selectively regulates the expression of c-Fos in the dorsal striatum of Parkinsonian mice[J]. Journal of Capital Medical University, 2021, 42(6): 986-992.

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Electroacupuncture selectively regulates the expression of c-Fos in the dorsal striatum of Parkinsonian mice

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