Abstract: Objective To explore the relationship between mean arterial pressure (MAP) variability and the mortality in intensive care unit (ICU) at the critically ill patients. Methods This is a retrospective analysis with 38 852 clinical data of critically ill patients in the Medical Information Mart for Intensive Care (MIMIC)-Ⅲ database. MAP variability was calculated by the coefficient of variation (CV) of MAP within 24 hours after admitted to ICU. According to the MAP variability within 24 hours, the patients were divided into 10 groups with equal frequency. Then, the general linear regression was used to assess the correlation between the MAP variability and the mortality in ICU.Area under the curve (AUC) of receiver operating characteristic (ROC) was applied to determine whether MAP variability can be a prognostic predictor on the in-ICU mortality in critically ill patients. Results There is a significant correlation between the 24-hour MAP variability and the mortality in ICU (R²=0.860, P <0.001). The larger the MAP variability, the higher the mortality in ICU. The AUC of 24-hour MAP variability prediction ICU mortality was 0.610. Conclusion The 24-hour MAP variability has a good correlation with the mortality in ICU at the critically ill patients. The greater the MAP variability, the higher the mortality in ICU. The MAP variability may provide some information for easily and quickly predicted the mortality in ICU of critically ill patients.

Key words: Medical Information Mart for Intensive Care-Ⅲ, mean arterial pressure variability, critically ill patients, mortality in intensive care unit