Abstract: Objective  To investigate the curative effect of letrozole combined with Zi Gui Nv Zhen Capsules on patients with polycystic ovary syndrome (PCOS) complicated by thin endometrial infertility. Methods  140 patients with PCOS who met the diagnosis of endometrial thin infertility (endometrial thickness<0.8 cm and no pregnancy for 1 year without contraception) were recruited and randomly assigned to the control group and the experimental group for 3 cycles of treatment. The control group was given letrozole 2.5 mg/d on the 3rd day of menstruation, estradiol valerate 2 mg/d on the 8-10th day of menstruation, and dydrogesterone 10 mg/d in sequence. The experimental group was treated with Zi Gui Nv Zhen Capsules on the basis of the control group. During 3 cycles of treatment, endometrial thickness (EMT), ovulation rate and cumulative pregnancy rate on the day of ovulation were examined.Results  The EMT of the experiment group was significantly higher than that of the control group on the ovulation day of three cycles ［(0.86±0.23) cm vs (0.71±0.15) cm；(0.83±0.26) cm vs (0.68±0.19)cm; (0.87±0.26) cm vs (0.71± 0.11) cm］, the cumulative pregnancy rate of experimental group was significantly higher than that of control group (44.3% vs 25.7%). There was no significant difference in ovulation rate between the two groups (P>0.05). Conclusion  Our findings demonstrate that the combined use of Zi Gui Nv Zhen Capsule with basic conventional therapy significantly enhances endometrial thickness and improves pregnancy rates in PCOS patients with thin endometrium.

Key words: Zi Gui Nv Zhen Capsules, letrozole, polycystic ovary syndrome (PCOS), thin endometrium, infertility, pregnancy rate