Research progress of epigenetics in the pathogenesis and treatment of migraine

doi:10.3969/j.issn.1006-7795.2026.01.023

Abstract

Abstract: Migraine is a severe chronic neurovascular disorder that significantly impacts patients' quality of life. Its pathophysiology is intricate, influenced by both genetic and environmental factors, yet existing treatments remain less than satisfactory. Epigenetics serves as a crucial bridge linking environmental and genetic factors. Increasing evidence indicates that epigenetic mechanisms are involved in migraine auras, attacks, and chronicity. These processes may serve as biomarkers for migraine diagnosis and prognosis, and as novel therapeutic targets. This paper provides a comprehensive review of the epigenetics of migraine, aiming to identify reliable biomarkers and therapeutic targets that advance migraine management.

Key words: migraine, epigenetics, DNA methylation, histone modification, non-coding RNA, biomarkers

CLC Number:

R394

Zhang Mengxi, Pang Miaoyi, Wang Peipei, Li Qian, Wang Yun, Yang Fei. Research progress of epigenetics in the pathogenesis and treatment of migraine[J]. Journal of Capital Medical University, 2026, 47(1): 180-189.

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