Journal of Capital Medical University ›› 2007, Vol. 28 ›› Issue (6): 753-755.

• 基础研究 • Previous Articles     Next Articles

The Study Protective Effects of 11,12-EET on I/R Heart in Rat

Yang Shaohua1, Zeng Xiangjun2, Wang Hongxia2, Yan Li2, Jiang Ying2, Hao Gang2, Zhang Like2   

  1. 1. Medical Experiment and Test Center, Capital Medical University;2. Department of Pathophysiology, School of Basic Medicine, Capital Medical University
  • Received:2006-10-09 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24

Abstract: Objective To study the protective effects of 11,12-EET on ischemia/reperfusion heart in rat at different times.Methods The ischemia/reperfusion rat model was established by coronary artery ligation and reperfusion,and 11,12-EET were given at different times and in different concentrations to monitor the ±dp/dtmax of rat heart.Results 6.24×10-7.5mol/L,6.24×10-8mol/L and 6.24×10-9mol/L 11,12-EET given before the establishment of ischemia showed certain protective effects on ischemia/reperfusion in rat heart function;6.24×10-8mol/L 11,12-EET given 24 h before the establishment ischemia/reperfusion however,showed no significant protective effect.Conclusion 11,12-EET have protective effects on ischemia/reperfusion heart in rat.

Key words: 12-EET, ischemia-reperfusion injury, rat, cardioprotection

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