Abstract: The targeting thrombolytic effects of P6A(ARPAK) and its derivatives,RGD peptides,nitronyl nitroxide containing peptides are reviewed.P6A,one of the degradation products from fibrinogen,is known to increase microvascular permeability and have thrombolytic effects.Its derivatives and degradation products also have potent thrombolytic effects.RGD is the key sequence in the binding of fibrinogen to platelet.The binding leads to thrombosis.Coupling RGD sequence to thrombolytic oligopeptide gives targeting thrombolytic oligopeptide.Sometimes the ischemia/reperfusion injury by free radicals is beyond thrombus itself.Binding free radical scavenger with thrombolytic oligopeptide gives peptide with two fold effects

Key words: targeting thrombolytic oligopeptide, P6A, RGD sequence, free radicals