Abstract: Objective To explore the early diagnosis and prognosis for cerebral venous sinus thrombosis(CVST).Methodes Retrospective analysis on the age and pattern of onset,first symptom,clinical characteristics, imaging characteristic,result of cerebrospinal fluid and prognosis in 29 CVST patients(male 11 and female 18).Results The CVST occurred in the second and fourth decades mainly;acute or subacute onset.The early clinical characteristics were headache(accounted for about 89.66% in all cases),vomit(accounted for about 55.17% in all cases),some accompanied with focal neurologic impairment or seizure.The imaging findings in CVST were venous sinus occlusion and local infarction(accounted for about 52% in all cases),some accompanied with capillary hemorrhage or haematoma(accounted for about 24% of cases).The intracranial pressure increased obviously in CVST patients,but the protein concentration and white blood cell count in CSF were normal or increased slightly.In addition,homocysteine occurred about 17% in CVST patients and all the patients were male.22 of 29 patients improved,2 of 29 patients recovered with occurred after focal thrombolysis with urokinase.The total effective ratio accounted for 82.81%,in addition,1 of 29 patients died.Among all the effective cases,10 cases were followed up for half a years,6 of 10 remained increased intracranial pressure.Conclusion The young patients who with acute headache attack,vomit,focal neurologic impairment or seizure,should be suspected CVST and even DSA and immediately undertaken the examination of CT,MRI,MRA and MRV in order to make a definite diagnosis.It is essential to treat with anticoagulant after the diagnosis of CVST.

Key words: venous sinus thrombosis, intracranial, clinical diagnosis