Abstract: Objective To observe the effect of desflurane on ultrastructure in rats with global cerebral ischemia reperfusion injury and investigate the cerebral protection action of deflurane.Methods Nine Wistar rats were randomly divided into 3 groups: ischemia group(n=3),desflurane group(n=3),and sham-operation group(n=3).Rat models with global cerebral ischemia-reperfusion were prepared.The desflurane inhalation for one hour was given immediately to the desflurane group when the reperfusion started.The brain was obtained 1 h after the ischemia-reperfusion in the ischemia and desflurane groups and after the operation in the sham-operation group.The changes of cortical ultrastructure were observed with electron microscope.Results The pyknosis of neurons in the desflurane group was less,and the organelle and microtubule-structure were basically normal,but the gliocytes and microcirculation were not improved,as compared with those of the ischemia group.Conclusion The results indicated that desflurane may have protective effects on neurons and cytoskeletons,but not on the gliocytes and microcirculations.

Key words: cerebral ischemia, reperfusion injury, desflurane, ultrastructure