Abstract: Objective To compare the therapeutic effect of Iodophor and iodine glycerin in treating gingivitis of rats.Methods The gingivitis animal model was made by suturing ligation of the neck on rat teeth and feeding with food containing high sugar.Animals were divided into groups of normal control,gingivitis,Iodophor and iodine glycerin.Local blood flow and aspartate aminotransferase levels were measured in gingival fluid after 7 d treatment.Results The gingiva of rats in gingivitis model group became red and swollen and formed false periodontal pocket.The quantity and cell number of blood flow and the gingival crevicular fluid aspartate aminotransferase(AST) levels in model group increased significantly(P<0.01) compared with control group.The quantity and cell number of blood flow and the gingival crevicular fluid AST levels in groups of iodophor and iodine glycerin were significantly lower(P<0.01) than those in model group.The quantity of blood flow and the gingival crevicular fluid AST levels in iodine glycerin group were significantly lower(P<0.01) than those in iodophor group.Conclusion The two drugs were effective in treating experimental gingivitis,and iodine glycerin is more effective than iodophor.

Key words: experimental gingivitis iodophor, iodophor, iodine glycerin