Abstract:

Objective To study the risk factors for poor prognosis in patients with liver cirrhosis. Methods A total of 337 cirrhosis patients were included in the study. The hospital records were analyzed retrospectively, and all patients were followed up by phone call or mail. The associated clinical and laboratory variables were studied by univariate and multivariate statistical analysis. Results ① The survival rates at 3-months, 6-months, 1-year, 3-years and 5-years after hospitalization were 89.0%, 87.8%, 82.2%, 77.4% 59.1% and 46.9%.② Univariate analysis shows that the factors associated with mortality during hospitalization were serum total bilirubin, direct bilirubin, albumin, creatinine, blood urea nitrogen, hemoglobin, prothrombin time, INR for prothrombin time and encephalopathy, hepatorenal syndrome, ascites, and upper gastrointestinal hemorrhage. ③ Univariate analysis showed that the factors associated with mortality 5-years after enrollment were serum total bilirubin, direct bilirubin, albumin, creatinine, blood urea nitrogen, hemoglobin, prothrombin time, INR for prothrombin time, cholesterol, low density lipoprotein, serum sodium and encephalopathy, hepatorenal syndrome, ascites and age. ④ Multivariate analysis showed that serum albumin, creatinine, blood urea nitrogen, total bilirubin, prothrombin time, low density lipoprotein, ascites and age were independently related to 5year mortality. Conclusion ① For cirrhotic patients, a number of clinical factors were significantly correlated with mortality in hospital or 5 years after enrollment. The liver function is the main factor for prognosis. ② Ascites and age were also significantly related to 5year mortality.

Key words: liver cirrhosis, prognosis, mortality, prognostic factors