Abstract:

The cell morphology and biochemical composition may be changed after cell senescence, it causes the physiological disorder, and then cells enter the apoptosis and death programs. Cell senescence is a mechanism to prevent immortalization and canceration and to prevent tumorigenesis at the cell level. It is caused by many reasons, during the recent years some researches find that the activation of p16INK4apRb pathway and p14ARFp53 pathway are closely correlated with the priming and adjusting process of cell senescence. The studies about the cell senescence signal transduction pathways and regulation factors can supply the research direction of the further knowledge of cell proliferation and senescence, the regulation of prevention and cure of tumor and the senescence correlated disease.

Key words: cell senescence, signal transduction pathway, p16INK4a, p14ARF