Abstract: It is sure that BNP plays a important role in regulation of aldosterone (Ald) secretion, but no one has reported that cerebral BNP (cBNP) and peripheral BNP (pBNP) have any difference in its regulation action.In order to solve this question, we have compared effects of cBNP administrated by icv and pBNP given by iv alone or associated with angiotensin II (AT-II), Adrenocorticotro-pin (ACTH) and Arginine Vasopressin (AVP) on regulation of Ald secretion.The results show that 1) AT-II, ACTHand AVP given by iv (5 μg/3ml· h^-1) could increase the concentration of plasma Aid.BNP (5μg/3ml· h^-1) inhibited the stimulation of ACTH and AVP, although BNP had not been discoved to have effect for AT-II; 2) BNP (2/μg in 10/μl NS)administrated by icy decreased the concentration of plas-ma Aid.icy injection of AVP (2 μg in 10 μl NS)could increase plasma Aid, but ACTH (2 μg in 10 μl NS) and AT-II (2 μg in 10 μl NS)did not have this effect.However, giving ACTH (2 μg in 10 μlNS) or AT-II(2 μg in 10 μl NS) individually with BNP (2 μg in 10 μl NS)could induce paradoxical stimulation on plasma Aid concentration, and 3) there were no effect on stimulation of Aid secretion induced by iv perfusion of AT-II, ACTH or AVP (5 μg/3ml· h^-1) when BNP (2 μg in 10 μl NS) was injected by icy.From above results, we found that there are certain differences between cBNP and pBNP on regulation of Aid secre-tion.Cerebral ACTH and AT-II can induce the increase of plasma Aid only in the condition of coo-peration with cBNP.

Key words: brain natriuretic peptide (BNP), aldosterone, angiotensin Ⅱ (AT-Ⅱ), adrenocorticotropin (ACTH), arginine vasopressin (AVP)