Abstract: Objective To investigate the effects of Myrtol Standardized on the regulation of healthy human nasal ciliary beat frequency(CBF) and its influence on nasal mucociliary transport time(MTT). Methods Changes in human nasal CBF in response to increasing concentrations of Myrtol Standardized within 20 minutes were quantified by using of high-speed digital microscopy. The MTTs before and after application of Myrtol Standardized in 12 patients with chronic rhinitis were determined by using the saccharin test. 9 patients were examined nasal function test. Results No statistically significant difference was identified when compared to basal CBF at the concentration of 75 μg/L, 150 μg/L or 300 μg/L, Myrtol Standardized. In addition, the use of Myrtol Standardized decreased the mean human nasal MTT from(12.8±4.5) to (9.3±3.8)min (n=12). Conclusion Myrtol Standardized significantly increased MTT in vivo, but no obvious effect on human nasal CBF in vitro was observed.

Key words: nasal mucosa, nasal mucociliary transport, cilia, mucociliary transport time