Changes of Enzymes Activities of Jejunum Mucosa in Severe Acute Pancreatitis in Rats

Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (3): 347-350.

• 基础研究 • Previous Articles Next Articles

Changes of Enzymes Activities of Jejunum Mucosa in Severe Acute Pancreatitis in Rats

Du Juan¹, Zhou Xiaona², Ma Tao², Wang Xiuqin¹, Gu Junchao², Zhang Lixin¹, Zeng Xiaobei¹, Sun Haimei¹, Li Baohong¹

1. Department of Histology and Embryology, Capital University of Medical Sciences;2. Department of General Surgery,Beijing Friendship Hospital, Capital University of Medical Sciences

Received:2005-05-11 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24

Abstract

Abstract: Objective To investigate the changes of enzymes activities of jejunum in rats with severe acute pancreatitis(SAP).Methods Rats were divided randomly into 3 groups:sham operation group (SO), SAP group, and treatment group with Gln (SAP+Gln).SAP model was reproduced by retrograde infusion of sodium taurocholate solution into the biliopancreatic duct. In addition, the SAP+Gln group was feeded with glutamine after operation. Tissues of jejunum were taken at 24 h, 48 h and 72 h respectively after operation, and the activities of alkaline phosphatase, ATPase, cytochrome oxidase, succinate dehydrogenase were studied using enzyme-histochemistry staining.Results The activities of ALP,ATPase,CCO,SDH decreased significantly in SAP group,while Gln could increase them significantly.Conclusion It suggest that the intestinal function was impaired in SAP.Gln could protect intestinal function.

Key words: sever acute pancreatitis, enzyme-histochemistry, jejunum, rat

CLC Number:

R322.81

Du Juan;Zhou Xiaona;Ma Tao;Wang Xiuqin;Gu Junchao;Zhang Lixin;Zeng Xiaobei;Sun Haimei;Li Baohong. Changes of Enzymes Activities of Jejunum Mucosa in Severe Acute Pancreatitis in Rats[J]. Journal of Capital Medical University, 2006, 27(3): 347-350.

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Changes of Enzymes Activities of Jejunum Mucosa in Severe Acute Pancreatitis in Rats

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