Abstract: Objective To study the causative agents and the clinical features of drug eruption of outpatients in our hospital from 2004 to 2005.Methods The clinical data of drug eruption in 186 outpatients were collected from 2004 to 2005 and the causative agents and clinical patterns were analyzed.Results 186 patients were enrolled in this study.The drugs most often responsible for the drug eruption were antimicrobials(38.7%)and Chinese patent medicine(26.9%).The most common clinical types were morbiliform-scarlatiniform exanthesis(69.4%),urticaria(18.8%) and fixed drug eruption(7.0%).The main causative agents of morbiliform-sarlatiniform exanthesis type and urticaria were antimicrobials(34.9%,45.7%) and Chinese patent medicine(27.9%,34.3%).The main causative drugs of life-threatening Steven-Johnson syndrome and dermatitis exfoliativa were antimicrobials and traditional Chinese medicine.Conclusion The most common causative agents in this study were antimicrobials and traditional Chinese medicine.More attention should be paid to increasing of drug eruption caused by traditional Chinese medicine,although most of them were gentle or midrange.

Key words: drug eruption, causative agents, clinical analysis