Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (3): 355-357.
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Wang Xianling1, Jia Jianping1, Zuo Pingping2, Yang Nan2
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Abstract:
Objective To investigate the pathogenetic mechanism of diabetic encephalopathy..Methods The non-insulin-dependent diabetes mellitus (NIDDM) animal models, KK-Ay mice, were used. Their cognitive performance and brain structure were studied. The activity of choline acetyltransferase (ChAT) was assayed with 3 H-CoA as the substrate and the binding activity of radiolabelled 3 H-QNB for acetylcholine muscarinic receptors (Mreceptors) was investigated in the cerebral cortex and hippocampus of KK-Ay mice..Results Cognitive impairment and changes of brain structure of NIDDM mice were found. In the cerebral cortex and hippocampus of KK-Ay mice, the activity of choline acetyltransferase (ChAT) was significantly reduced at 12 weeks of duration compared with that of age-matched controls. The binding activity of 3 H-QNB for M receptor in the diabetic mice was not significantly different from that of the controls..Conclusion The acetylcholine system deficits are closely related to the cognitive impairment of diabetic mice.
Key words: diabetic encephalopathy, choline acetyltransferase(ChAT), M receptor
CLC Number:
R587.1
R338
Wang Xianling;Jia Jianping;Zuo Pingping;Yang Nan. Study on the Acetylcholine System in the Brain of Non-Insulin-Dependent Diabetes Mellitus Animal Model, KK-Ay Mice[J]. Journal of Capital Medical University, 2006, 27(3): 355-357.
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https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2006/V27/I3/355