Changes in Expression of UⅡ and Its Receptor in 2DM Mouse Liver

Abstract

Abstract: Objective To study the expression changes of UⅡ and its receptor in 2DMmouse liver.Methods Blood glucose monitoring device was used to examine the concentration of fast blood glucose.Radioimmunity assay method was used to examine the concentration of plasma UⅡ and insulin.RT-PCR method was used to assay the expression of GPR14 mRNA in mouse liver.Immunohistochemistry method was used to assay UⅡ immunological activity expression in mouse liver.Results Compared with control group,the concentration of fasting blood glucose,plasma insulin and plasma UⅡ increased in 2DM group,immunological activity of UⅡ was strong positive expression in 2DM mouse liver,the expression of GPR14 mRNA was up-regulated in 2DM mouse liver.Conclusion It is possible that the increasing expression of UⅡ derived from liver is a source of plasma UⅡ.But it is unclear what relevance the up-regulated expression of GPR14 mRNA has with 2DM and deserves further study.

Key words: type 2 diabetes, urotensin Ⅱ, G protein coupled receptor

CLC Number:

R332
R322.11

Wang Hongxia;Zeng Xiangjun;Wang Jue;Lu Lingqiao;Mu Jing;Chang Jing;Zhang Like. Changes in Expression of UⅡ and Its Receptor in 2DM Mouse Liver[J]. Journal of Capital Medical University, 2008, 29(6): 741-744.

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Changes in Expression of UⅡ and Its Receptor in 2DM Mouse Liver

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