Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (2): 115-118.

• 临床研究 • Previous Articles     Next Articles

Effect of APP17 Peptide on the Hippocampal Neurons Ultrastructure and Expression of InsR, Ins-1 in Type 2 Diabetic KKAy Mice

Zhuang Xiaoming1, Zhao Zhiwei2, Ji Zhijuan2, Zhao Yongmei2, Sheng Shuli 2   

  1. 1. epartment of Endocrinology, Beijing Fuxing Hosptial, Affiliate of Captial University of Medical Sciences;2. Beijing Research Laboratory for Brain Aging, Xuanwu Hospital
  • Received:2002-01-14 Revised:1900-01-01 Online:2002-04-15 Published:2002-04-15

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Abstract: The objective of the study was to investigate the expression of apoptotic-related proteins in hippocampal neurons of KK mice and the hippocampus ultrastructure in diabetic KK mice. KK mice were divided into three groups: normal control group, diabetic group and diabetic group treated with APP17-mer peptide. After 12 weeks, crystat sections of mouse brain were prepared and immunohistochemically stained for InsR, IRS-1. Three groups of the mice were observed and analyzed by electron microscopy. The levels of blood glucose and plasma insulin in DM group and DM+APP17P group were significantly increased and compared with C group. There were no significant difference between DM group and DM+ APP17P group. The expression of InsR, IRS-1 significantly decreased in diabetic mice as compared with normal controls(P<0.05), and find mitochondria edema in hippocampus in DM group. APP17 peptide may activate the signal transductive pathway. It may also improve the apoptosis of neuron in type 2 diabetic KK mice.

Key words: APP17 peptide|type 2 diabetes|signal transduction pathway

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