G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012

doi:10.3969/j.issn.1006-7795.2012.05.029

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (5): 695-699.doi: 10.3969/j.issn.1006-7795.2012.05.029

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G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012

ZHANG Chen-guang, DING Wei

Department of Medical Genetics, Capital Medical University, Beijing 100069,China

Received:2012-10-14 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

Abstract

Abstract: Two American scientists Robert Lefkowitz and Brian Kobilka have honored the 2012 Nobel Price in Chemistry for their achievements in the G protein coupled receptor (GPCR) studies. In this article, we introduced their research in the related fields and summarized their major academic contributions that recognized among scientific researchers. Furthermore, we expanded the discussion regarding the significance and the potential applications of their work for morden medication and drug development.

Key words: Nobel Prize in Chemistry, G protein coupled receptor, signal transduction, drug development, structural biology

ZHANG Chen-guang;DING Wei. G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012[J]. Journal of Capital Medical University, 2012, 33(5): 695-699.

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G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012

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