Abstract:

Objective To explore the infection-endurance ability of the novel complex mesh combined by polypropylene(PP) and acellular tissue matrix(ACTM) in contaminative condition. Methods A total of 60 New Zealand white rabbits were randomized divided into two groups(n=30), the experiment group animals were treated with the novel complex mesh of PP and ACTM(IPOM method) and the control group animals were treated with the traditional complex mesh of PP and expanded polytetrafluoroethy-lene(e-PTFE )(IPOM method) respectively. Meanwhile, the mesh was contaminated with the rabbit intestinal juice in each group before the incision was closed. The infected state of the mesh was observed and specimens for pathological examination were collected during the first month after the operation. Results Only one case of the experiment group and 8 cases of control group appeared infected. It was prone to find fibroblasts proliferation and neovascularization by pathological examination in experiment group. Significant difference was found between the two groups. Through bacterial culture we found Escherichia coli in the infected mesh. Conclusion Compared with the traditional complex mesh of PP and e-PTFE, the novel complex mesh of PP and ACTM had powerful endurance in intestinal juice contaminative condition. The mechanism might be involved in the fibroblast proliferation and neovascularization.

Key words: complex mesh, infection, intestinal juice