Abstract: Objective To analyze the current situation, distribution characteristics and molecular typing composition of Helicobacter pylori (Hp) infection in patients with digestive system diseases in Beijing Anzhen Hospital, Capital Medical University using Taqman probe molecular assays, so as to provide theoretical basis for prevention and treatment of Hp infection and clinical medication. Methods 10839 patients who underwent gastroscopy from April 2018 to September 2019 were selected for Hp molecular detection, molecular typing and infection degree classification. The detection rate and molecular typing composition of Hp in different months, different quarters, different genders and different ages were analyzed. Results Among the 10839 subjects, the positive rate of Hp was 33.76%, and the positive rate of males was higher than that of females (P<0.05). The positive rate of Hp was the highest in summer. It increased at first and then decreased with the increase of age. The positive rate of Hp reached the peak in the age group of 40 years old. There were significant differences in the detection rate of Hp among different seasons and different age groups (P<0.05). In the two molecular types of Hp, the detection rate of type Ⅰ in males was higher than that in females (P<0.05). Conclusion The positive rate of Hp in male is higher than that in female, the detection rate of Hp is related to season and age, and the detection rate of Hp in type Ⅰ is higher than that in type Ⅱ.

Key words: Helicobacter pylori, molecular detection, molecular subtype, infection