Changes of neutrophil gelatinase-associated lipocalin in patients with primary hypertension and its clinical significance

doi:10.3969/j.issn.1006-7795.2013.04.025

Journal of Capital Medical University ›› 2013, Vol. 34 ›› Issue (4): 605-608.doi: 10.3969/j.issn.1006-7795.2013.04.025

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Changes of neutrophil gelatinase-associated lipocalin in patients with primary hypertension and its clinical significance

HOU Fei¹, MIAO Jieping¹, CAI Hongmei¹, NIU Dong², LI Zhenwen³, MA Jiedan¹, LIU Jing⁴

1. Division of Nephrology, Beijing Electric Power Hospital, Teaching Hospital of Capital Medical University, Beijing 100073, China;
2. Infirmary, The Third Hospital of Beijing Group, China Armed Police Force, Beijing 100141, China;
3. Clinical Laboratory, Beijing Electric Power Hospital, Teaching Hospital of Capital Medical University, Beijing 100073, China;
4. Division of Neurology, Beijing Electric Power Hospital, Teaching Hospital of Capital Medical University, Beijing 100073, China

Received:2012-12-17 Online:2013-08-21 Published:2013-07-20
Supported by:
This study was supported by North China Grid Company Limited Labor hygiene and Occupation Disease Research Institute(8AE000310003).

Abstract

Abstract:

Objective To investigate the changes of serum and urine neutrophil gelatinase-associated lipocalin(NGAL) in patients with primary hypertension and its clinical significance. Methods A total of 117 patients with primary hypertension and 110 healthy persons were studied. We detected serum and urine NGAL protein levels with enzyme linked immunosorbent assay(ELISA), serum creatinine(Scr) and urine β2-mG. Results The concentration of serum NGAL in hypertensive patients were(1.88±1.49)μg/L, urine NGAL were(1.19±0.64)μg/L, the serum NGAL of control group were(0.78±1.01)μg/L, urine NGAL were(0.58±0.32)μg/L. Serum and urine NGAL were significantly higher in patients with hypertension than the control group(P<0.05). The difference between hypertension group and control group in urine β2-mG was statistically significant(P<0.05), but not in Scr(P>0.05). Conclusion The serum and urine NGAL levels of patients with primary hypertension were significantly higher, detection of serum and urine level of NGAL in hypertension patients may have an important clinical significance in diagnosis, treatment and prognosis of hypertensive nephropathy.

Key words: neutrophil gelatinase-associated lipocalin, primary hypertension, hypertensive nephropathy

CLC Number:

HOU Fei, MIAO Jieping, CAI Hongmei, NIU Dong, LI Zhenwen, MA Jiedan, LIU Jing. Changes of neutrophil gelatinase-associated lipocalin in patients with primary hypertension and its clinical significance[J]. Journal of Capital Medical University, 2013, 34(4): 605-608.

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Changes of neutrophil gelatinase-associated lipocalin in patients with primary hypertension and its clinical significance

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