Effects and possible mechanisms of pancreatic duct epithelial cells on insulin secretion of the islet β cells

doi:10.3969/j.issn.1006-7795.2014.01.017

Abstract

Abstract:

Whereas the endocrine and the exocrine pancreas have been generally regarded as independent entities in morphology and function, evidence for close interactions between the two glandular components has been obtained. A recent report has suggested that substance secreted into the pancreatic juice could exert an action on islet cells that directly face the duct lumina, and eventually bring a peculiar stimuli to a larger population of islet cells through gap junctions among them. Pancreatic duct epithelial cells secretc pancreatic juice rich in sodium bicarbonate which may have a functional effect on islet cells. It has long been recognized that cystic fibrosis transmembrane conductance regulator (CFTR) is abundant in small pancreatic duct epithelial cells and quite important for the secretion of bicarbonate. However, the expression of CFTR in pancreatic islet is not completely defined and few studies have reported about the role of CFTR expressed in islet cells. Further study on the influence and mechanism of pancreatic duct epithelial cells to the islet is needed, and it may be meaningful for the prevention, therapy of and perhaps the new drug for diabetes mellitus.

Key words: pancreatic duct epithelial cell, NaHCO₃, cystic fibrosis transmembrane conductance regulator, insulin secretion

CLC Number:

Lyu Xiaohong, Wang Lei, Liu Chang, Wang Yingying, Yang Jinkui. Effects and possible mechanisms of pancreatic duct epithelial cells on insulin secretion of the islet β cells[J]. Journal of Capital Medical University, 2014, 35(1): 77-80.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.01.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I1/77

References

[1] Bensley R R. Studies on the pancreas of the guinea pig[J]. Am J Anat, 1911, 12(3):297-388.

[2] Van Suylichem P T, Wolters G H, van Schilfgaarde R. PerⅡnsular presence of collagenase during islet isolation procedures[J]. J Surg Res, 1992, 53(5):503-509.

[3] Bertelli E, Regoli M, Orazioli D, et al. Association between islets of Langerhans and pancreatic ductal system in adult rat. Where endocrine and exocrine meet together?[J]. Diabetologia, 2001, 44 (5): 575-584.

[4] Bouwens L, Pipeleers D G. Extra-insular beta cells associated with ductules are frequent in adult human pancreas[J]. Diabetologia, 1998, 41(6):629-633.

[5] Zhao H L, Sui Y, Guan J, et al. Topographical associations between islet endocrine cells and duct epithelial cells in the adult human pancreas[J]. Clin Endocrinol(Oxf), 2008, 69(3):400-406.

[6] Pavlovic D, Chen M C, Bouwens L, et al. Contribution of ductal cells to cytokine responses by human pancreatic islets[J]. Diabetes, 1999, 48(1):29-33.

[7] Bouwens L, Lu W G, De Krijger R. Proliferation and differentiation in the human fetal endocrine pancreas[J].Diabetologia, 1997, 40(4):398-404.

[8] Wang R N, Bouwens L, Klppel G. Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capability[J]. Diabetologia, 1994, 37(11):1088-1096.

[9] Inada A, Nienaber C, Katsuta H, et al. CAⅡ positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth revision[J]. Proc Natl Acad Sci USA, 2008, 105(50):19915-19919.

[10] Wang R N, Klppel G, Bouwens L. Duct-to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats[J]. Diabetologia, 1995, 38(12):1405-1411.

[11] Bonner-Weir S, Toschi E, Inada A, et al. The pancreatic ductal epithelium serves as a potential pool of progenitor cells[J].Pediatr Diabetes, 2004, 5 Suppl 2: 16-22.

[12] Li L, Seno M, Yamada H, et al. Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats[J]. Endocrinology, 2001, 142(12):5379-5385.

[13] Zhang Y Q, Zhang H, Maeshima A, et al. Up-regulation of the expression of activins in the pancreatic duct by reduction of the beta-cell mass[J].Endocrinology, 2002, 143(9):3540-3547.

[14] Ilieva A, Yuan S, Wang R N, et al. Pancreatic islet cell survival following islet isolation: the role of cellular interactions in the pancreas[J]. J Endocrinol, 1999, 161(3): 357-364.

[15] Gatto C, Callegari M, Folin M, et al. Effects of cryopreservation and coculture with pancreatic ductal epithelial cells on insulin secretion from human pancreatic islets[J]. Int J Mol Med, 2003, 12(6): 851-854.

[16] Murray H E, Paget M B, Bailey C J, et al. Sustained insulinsecretory response in human islets co-cultured with pancreatic duct-derived epithelial cells within a rotational cell culture system[J]. Diabetologia, 2009, 52(3): 477-485.

[17] Weksler-Zangen S, Raz I, Lenzen S, et al. Impaired glucose stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat[J]. Diabetes, 2008, 57(2):279-287.

[18] Street C N, Lakey J R, Shapiro A M, et al. Islet Graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome[J]. Diabetes, 2004, 53(12):3107-3114.

[19] Bertelli E, Regoli M, Bastianini A. Endocrine tissue associated with the pancreatic ductal system:a light and slectron microscopic study of the adult rat pancreas with special reference to a new endocrine arrangement[J].Anat Rec, 1994, 239(4):371-378.

[20] Dalli J, Rosignoli G, Hayhoe R P, et al.CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway[J]. Am J Pathol, 2010, 177(1):176-186.

[21] Moran A, Dunitz J, Nathan B, et al. Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality[J]. Diabetes Care, 2009, 32(9):1626-1631.

[22] Stecenko A A, Moran A. Update on cystic fibrosis-related diabetes[J].Curr Opin Pulm Med, 2010, 16(6):611-615.

[23] Chen M H, Chen H, Zhou Z, et al. Involvement of CFTR in oviductal HCO3 2 secretion and its effect on soluble adenylate yclase-dependent early embryo development[J]. Hum Reprod, 2010, 25(7):1744-1754.

[24] Ishiguro H, Steward M C, Naruse S, et al.CFTR functions as a bicarbonate channel in pancreatic duct cells[J]. J Gen Physiol, 2009, 133(3):315-326.

[25] Song Y, Ishiguro H, Yamamoto A, et al. Effects of Slc26a6 deletion and CFTR inhibition on HCO₃^-secretion by mouse pancreatic duct[J].J Med Invest, 2009, 56 suppl:332-335.

[26] Stalvey M S, Muller C, Schatz D A, et al. Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after β-cell injury[J].Diabetes, 2006, 55(7):1939-1945.

[27] Boom A, Lybaert P, Pollet J F, et al. Expression and localization of cystic fibrosis transmembrane conductance regulator in the rat endocrine pancreas[J]. Endocrine, 2007, 32(2): 197-205.

[28] Ali B R. Is cystic fibrosis-related diabetes an apoptotic consequence of ER stress in pancreatic cells?[J]. Med Hepotheses, 2009, 72(1):55-57.