Journal of Capital Medical University ›› 2011, Vol. 32 ›› Issue (2): 259-262.

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Comparison of the Number of Decidual Natural Killer Cells between Decidua Basalis and Decidua Parietalis in Human First Trimester

WANG Wei1, WANG Jing2, WENG Jing2*   

  1. 1. Department of Histology and Embryology, Yanjing Medical College, Capital Medical University; 2. Department of Histologyand Embryology, School of Basic Medical Sciences, Capital Medical University
  • Received:1900-01-01 Revised:1900-01-01 Online:2011-04-21 Published:2011-04-21
  • Contact: WENG Jing

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Abstract:

Objective To investigate the human decidual natural killer(dNK) cells in decidua basalis(DB) and decidua parietalis(DP) during early pregnancy and its possible functions.
Methods DB and DP of the same early pregnant individual were discriminated by HE staining and expression of Keratin 7 by immunohistochemistry. The CD56+ dNK cells were shown by immunohistochemistry. The number of dNK cells in DB or DP was counted.
Results Cytokeratin 7-positive extravillous trophoblast cells was a marker to distinguish DB and DP because they only present in DB. The number of CD56+ dNK cells in DB was significantly larger than that in DP(P<0.01).
Conclusion The differential distribution of dNK cells in early pregnant decidua may be related to trophoblast invasion.

Key words: decidual natural killer cells, decidua basalis, decidua parietalis

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