Journal of Capital Medical University ›› 2016, Vol. 37 ›› Issue (1): 83-88.doi: 10.3969/j.issn.1006-7795.2016.01.016

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Research highlights analysis of foreign liver fibrosis diagnosis

Zhang Hong1, Tao Sen2, Hao Yu3, Zhao Ziwei3, Liu Nibo3, Wang Hongwu3   

  1. 1. Department of Chronic Liver Disease, Tianjin Secondary People Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300092, China;
    2. Department of Hepatobiliary, The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;
    3. Department of Epidemiology, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2015-07-17 Online:2016-02-21 Published:2016-02-01
  • Supported by:
    This study was supported by Open Research Project of Beijing Key Laboratory for Hypoxic Preconditioning and Translational Medicine(2015DYSY02).

Abstract: Objective To explore the research situation in abroad of liver fibrosis in chronic liver disease the last ten years. Methods The English literatures which were involved in liver fibrosis diagnosis from 1995 to 2014 have been retrieved on PubMed, Embase, Web of science. The bibliometric analysis has been operated with Endnote X7, Bicomb2.0 software.The high frequency keywords of liver fibrosis diagnostic test have been defined by the frequency not less than 40. At last, the high frequency keywords have been put into SPSS20.0 and made cluster analysis.Results A total of 1 253 available literatures have been screened, roughly the amount of literatures published on the rise. The 5 767 key words of liver fibrosis diagnostic test have been screened. The most frequent key words are biopsy,biological markers and elastography in the order. Conclusion Biopsy is still the diagnostic reference standard of liver fibrosis. Serological examination is common testing method. Imaging,especially ultrasonic elasticity measurement has been major noninvasive diagnostic means.

Key words: liver fibrosis, diagnosis, bibliometric analysis

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