Primary malignant mediastinal germ cell tumor: report of two cases and literature review

doi:10.3969/j.issn.1006-7795.2016.05.003

Abstract

Abstract: Objective To improve the recognition of primary malignant mediastinal germ cell tumor (PMMGCT). Methods We describe in detail the clinical data of 2 patients with PMMGCT, and reviewed the relevant literature. Results Patient 1, a 22-year-old man, presented with cough and dyspnea for 5 months. Chest CT showed a large homogeneous mass. Serum beta human chorionic gonadotrop(h)in (β-HCG) level was elevated. Ultrasound-guided biopsy confirmed seminoma. Patient 2, a 20 year-old man, presented with chest pain for 10 days. Chest CT showed a large heterogeneous mass, and his serum alpha-fetoprotein (AFP) level elevated significantly. CT-guided biopsy confirmed yolk sac tumor. PMMGCT is seen almost exclusively in young men. Symptoms usually are nonspecific. Chest CT often shows a large heterogeneous mass with obliteration of adjacent fat planes. Elevated serum AFP or β-HCG can be used as diagnostic clues. PMMGCT are highly sensitive to cisplatin-based chemotherapy, followed by radiotherapy or surgical resection. Conclusion PMMGCT patients are rarely seen clinically. Respiratory and radiological physicians should raise awareness and strive for a better prognosis.

Key words: anterior mediastinal masses, primary malignant mediastinal germ cell tumors, diagnose, treatment

CLC Number:

R734.5

Lu Ming, Chen Hongshan, Han Xiang, Yang Wei, Zhu Xiang, Zhu Hong, He Bei, Yao Wanzhen. Primary malignant mediastinal germ cell tumor: report of two cases and literature review[J]. Journal of Capital Medical University, 2016, 37(5): 574-578.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.05.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I5/574

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