Abstract: Objective To investigate the clinical significance of the platelet membrane glycoproteins in various periods of ischemic cerebrovascular diseases. Methods Peripheral blood platelet activation markers GPⅢa(CD61), GPⅠb(CD42b) and GPⅠa(CD49b) in 108 patients with ischemic cerebrovascular diseases(20 TIAs, 49 lacunar infarcts and 39 cerebral thrombosis) were detected in various periods(acute stage≤3 days, one week, two weeks and convalescence stage) by the method of quantitative flow cytometry. Thirty normal aged persons served as controls. The degree of neurologic impairment were analyzed by ESS grading. Results GPⅢa expression increased significantly(P<0.05) within one week of TIA and in acute stage of both cerebral thrombosis. In convalescence stage, the GPⅠa expression in cerebral thrombosis was significantly higher than those of in lacunar infarcts. Peripheral blood GPⅠa slightly stepped up in acute stage but decreased in convalescence stage(P>0.05). ESS grading was accociated with GPⅠb(pearson analysis, r=0.233, P<0.05) and these GPs were associated with one another by partial correlation analysis. Conclusion GPⅢa and GPⅠb were significantly activated in the acute phase of cerebral thrombosis and TIAs, which was very important in the course of thrombosis. The changes in GP may reflect a prothrombotic state and they may be predictive factors to the progress and prognosis of some ischemic cerebrovascular diseases.

Key words: ischemic cerebrovascular diseases, platelet membrane glycoprotein, quantitative flow cytometry