Journal of Capital Medical University ›› 2018, Vol. 39 ›› Issue (2): 204-208.doi: 10.3969/j.issn.1006-7795.2018.02.010

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Relationship between Traditional Chinese Medicine constitution classifications and the side effects of antipsychotic drugs

Yu Ying1,2, Zhuang Hongyan1, Yin Dongqing1, Du Jian3, Yang Jing4, Jia Hongxiao1   

  1. 1. Chinese Medicine Research Center, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
    2. The Second Department of Psychiatry, Beijing Daxing District Psychiatric Hospital, Beijing 102600, China;
    3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences, Beijing 100700, China;
    4. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2017-01-26 Online:2018-03-21 Published:2018-04-14
  • Supported by:
    This study was supported by Natural Science Foundation of Beijing (7152069), Clinical Characteristics Program of Beijing Municipal Science and Technology Commission (Z151100004015061).

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Abstract: Objective To study the relationship between Traditional Chinese Medicine (TCM) constitution classifications and the side effects of antipsychotic drugs. Methods Totally 233 patients of Beijing Anding Hospital of Capital Medical University treated with equivalent doses of antipsychotics were divided into research group and control group,119 cases with severe side effects of antipsychotic drugs were set as research group and 114 cases with gentle ones were set as control group. The nine standardized TCM Constitution Questionnaire survey methods were used to carry out the TCM constitution identification. Treatment Emergent Symptom Scale (TESS) was used to assess the severity of the side effects of antipsychotic drugs. Results There were the difference between research group and control group in the distribution of constitution in TCM(χ2=16.68,P<0.05);The distribution ratios of the patients with the Blood-stasis constitution and the Qi-depression constitution in research group were greater than that in control group(χ2=4.56,4.24,P<0.05). There was positive correlation with the patients with the blood-stasis constitution and the qi-depression constitution and aggregate score of TESS with statistically significance (r=0.25,0.29,P<0.01). The patients with the blood-stasis constitution and the cardiovascular system subscale scores from TESS showed positive correlation,with statistically significance (r=0.31,P<0.01). The patients with the qi-depression constitution and the autonomic nerve subscale scores from TESS showed positive correlation,with statistically significance (r=0.214,P<0.05). Conclusion The patients with blood-stasis constitution and the qi-depression constitution were more likely to experience side effect:those with the blood-stasis constitution are more likely to have the side effects of cardiovascular system and those with the qi-depression constitution were more likely to have the side effects of autonomic nervous system.

Key words: antipsychotic drugs, side effects, constitution in Traditional Chinese Medicine

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