A Meta-analysis of the relationship between cervical high-risk HPV infection and vaginal microecology in Chinese women

doi:10.3969/j.issn.1006-7795.2018.06.010

Abstract

Abstract: Objective To conduct a comprehensive and systematic review concerning the relationship between cervical high risk-human papillomavirus (HR-HPV) infection and vaginal microecology, as there are inconsistent conclusions about epidemiological studies among Chinese women. Methods CNKI, Wanfang, Pubmed and other databases were retrieved. The correlation between cervical HR-HPV infection and vaginal microecology in Chinese female was collected by literature retrospective method. The original literatures of case-control studies were collected. The infection rates of HR-HPV and trichomonal vaginitis (TV), bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) and lactobacillus abnormalities were evaluated according to the original data in the literature. Stata 14.0 software was used to analyze the data, and Egger's test was used to evaluate the publication bias. Results A total of 20 literatures and 20 case-control studies were included. The results showed that cervical HR-HPV infection was associated with BV, VVC and lactobacillus abnormalities in Chinese women. The odds ratios (ORs) were 2.23[95% confidence interval (CI):0.99-2.13], 1.55 (95% CI:1.12-2.12) and 3.55 (95% CI:2.21-5.71), respectively. It is statistically significant and has no publication bias. The association between HR-HPV infection and TV remains to be discussed. The combined OR value was 1.45 (95% CI:0.99-2.13), but there was no statistical significance and had publication bias. Conclusion Cervical HR-HPV infection is closely related to vaginal microecology. BV, VVC and lactobacillus abnormalities are high-risk factors for cervical HR-HPV infection.

Key words: high risk-human papillomavirus infection, microecology, Meta-analysis

CLC Number:

R737.33

Zhang Xuefang, He Xin, Huang Wenyang, Li Weihua, Luo Mei, Zhang Yang, Wang Shuzhen. A Meta-analysis of the relationship between cervical high-risk HPV infection and vaginal microecology in Chinese women[J]. Journal of Capital Medical University, 2018, 39(6): 841-848.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.06.010

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I6/841

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