Application of functional near-infrared spectroscopy in the treatment of mild cognitive impairment after stroke with repeated transcranial magnetic stimulation

doi:10.3969/j.issn.1006-7795.2020.06.016

Abstract

Abstract: Objective To explore the effects of high-frequency repeated transcranial magnetic stimulation (rTMS) on mild cognitive impairment and oxyhemoglobin concentration levels of prefrontal lobe in stroke patients. Methods Sixty patients with mild cognitive impairment after stroke were randomly divided into the rTMS group (n=30) and the control group (n=30). Both groups received 8 weeks of routine rehabilitation training,while the rTMS group received additionally 15 Hz rTMS during the treatment. Two groups of patients were assessed with the Mini-mental State Examination(MMSE) and the Montreal Montreal Cognitive Assessment (MoCA) before treatment (T0),4 weeks (T1) and 8 weeks (T2) after treatment. The patients were also examined with functional near-infrared spectroscopy (fNIRS). Results After 8 weeks of treatment(T2),MMSE,MoCA score, and the concentration of oxyhemoglobin in the rTMS group were significantly higher than those in the control group (P＜0.01),and the peak time of oxyhemoglobin concentration in the rTMS group was significantly shorter than that in the control group (P＜0.01). MMSE,MoCA score, and oxyhemoglobin concentration in the rTMS group after 8 weeks (T2) were significantly higher than that before treatment(T0)(P＜0.001). There was a positive correlation between MMSE,MoCA score, and oxyhemoglobin concentration (P＜0.001). Conclusion High-frequency rTMS improved mild cognitive impairment after stroke and increased the concentration of oxyhemoglobin in frontal lobe.

Key words: stroke, repetitive transcranial magnetic stimulation, cognition, functional near-infrared spectroscopy

CLC Number:

R743

Zhang Yingbin, Mo Linhong, Nie Yiqiu, Liu Aixian. Application of functional near-infrared spectroscopy in the treatment of mild cognitive impairment after stroke with repeated transcranial magnetic stimulation[J]. Journal of Capital Medical University, 2020, 41(6): 965-969.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.06.016

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I6/965

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