Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (2): 239-242.doi: 10.3969/j.issn.1006-7795.2021.02.013

• Basic Research on Cerebral lschemic Injury • Previous Articles     Next Articles

Application of ultrasound-guided femoral artery puncture and catheterization on endovascular ischemic stroke models of adult rhesus monkeys

Ma Yanhui1, Wu Jie1, Jia Bin1, Yao Dongxu1, Xu Na1, Wang Tianlong1, Chen Jian2, Wu Di2, *   

  1. 1. Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
    2. China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2021-01-14 Published:2021-04-26
  • Contact: *E-mail:di.wu@xwhosp.org
  • Supported by:
    This study was supported by National Natural Science Foundation of China (81871022,82071466).

Abstract: Objective Investigate the effect of ultrasound-guided femoral artery puncture and catheterization in the development of ischemic stroke models of adult rhesus monkeys through endovascular methods.Methods Sixteen male rhesus monkeys were randomized into 2 groups: control group (Group C) and ultrasound-guided group (Group U). Su-mian-xin injection combined with 0.1 mL/kg ketamine was given before endotracheal intubation. After intubation, the animals received mechanical ventilation. Anesthesia was maintained with propofol infusion (5-8 mg·kg-1·h-1) in both groups. Classic palpation method was used for femoral artery puncture and catheterization in Group C. Ultrasound-guidance combined in-plane and out-of-plane was used for femoral artery puncture and catheterization in Group U. The first attempt success rate, second attempt success rate, total success rate, numbers of attempts, period of puncture and catheterization time and incidence of complications were compared between two groups. Results The frequency of attempts in Group U was less than that in Group C (P<0.05). Compared with Group C, the mean time to success was shorter in Group U (P<0.05). The success rate of the first and second attempt and total success rates were high in Group U, with no statistical differences (P>0.05). There was no difference in the incidence of complications between the two groups (P>0.05). Conclusion Ultrasound-guidance combined in-plane and out-of-plane used for femoral artery puncture and catheterization improved the initial attempt success rate and total success rate, reduce the frequency of attempts and the mean time on endovascular ischemic stroke models of adult rhesus monkeys.

Key words: rhesus monkeys, middle cerebral artery occlusion, femoral artery puncture and catheterization, ultrasound-guided

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