Progress in neoadjuvant immunotherapy for resectable non-small cell lung cancer

doi:10.3969/j.issn.1006-7795.2021.05.027

Abstract

Abstract: Resectable non-small cell lung cancer (NSCLC) is known as a potentially curable disease. Radical surgery or adjuvant chemotherapy and radiotherapy is the standard treatment, but quite a few patients will have local recurrence and distant metastasis after surgery. More recent publications indicate that immune checkpoint blockade may have better potential in neoadjuvant therapy, with reported major pathological response rates of 20% to 85%, compared to chemotherapy alone. This review intends to summarize the efficacies and potential risks of neoadjuvant targeted therapy and immunotherapy in patients with NSCLC. With more and more independent research and development of immune checkpoint inhibitors listed in China,we discussed the future developments in neoadjuvant therapy.

Key words: non-small cell lung cancer, resectability, immune checkpoint inhibitors, neoadjuvant therapy

CLC Number:

R734.2

Tan Xiaogang, Zhang Yi. Progress in neoadjuvant immunotherapy for resectable non-small cell lung cancer[J]. Journal of Capital Medical University, 2021, 42(5): 862-867.

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