To explore the influence of lenticulostriate artery on quantitative perfusion of basal ganglia brain tissue and predict the prognosis of patients

doi:10.3969/j.issn.1006-7795.2022.01.011

Abstract

Abstract: Objective Vessel wall imaging (VWI) and self-calibrated echo planar perfusion weighted imaging(SCALE-PWI) were used to explore the effects of imaging characteristics of lenticulostriate artery(LSA)on lacunar infarction (LIs) and cerebral tissue perfusion in the basal ganglia region, and its correlation with the severity and prognosis of stroke.Methods A retrospective analysis was performed on 46 patients with ischemic stroke or transient ischemic attack who underwent VWI and scale-PWI examinations in Tianjin First Central Hospital from January 2018 to January 2021.According to National Institute of Health Stroke Scale(NIHSS) score at discharge, the patients were divided into good prognosis group (≤6) and poor prognosis group (＞6). The LSA parameters (number, total length and curvature of LSA) in VWI images were measured;the differences of clinical baseline data between the good prognosis group and the bad prognosis group were compared, the differences of symptom side LSA parameters, cerebral blood flow (CBF),cerebral blood volume (CBV) and infarction volume were compared between the two groups. The correlation between imaging parameters and admission NIHSS score, and the indicators affecting poor prognosis of patients were evaluated. Finally, the diagnostic efficacy of significant indexes between poor prognosis group and good prognosis group was evaluated. Results There were significant differences in the number of LSA (P=0.015), total length of LSA (P=0.032), CBF (P=0.001) and CBV (P<0.001) of basal ganglia between the good prognosis group and the bad prognosis group. Multiple linear regression analysis showed that infarct volume could predict stroke severity (F=7.408, P=0.002) indicating that the regression model was statistically significant. After adjusting for age, gender, hypertension and diabetes, the CBV of the affected side was still an important indicator of improvement, with an area under the ROC curve of 0.922 (95% CI: 0.904-0.981). Conclusion LSA features from VWI can reflect the perfusion status of basal ganglia, and quantitative cerebral perfusion parameters of basal ganglia are influential factors for poor prognosis of LIs patients.

Key words: lenticulostriate artery, cerebral perforating artery disease, middle cerebral artery, perfusion, high resolution vascular wall imaging

CLC Number:

R445

Huang Lixiang, Wang Shaozhou, Cao Chen, Xia Shuang. To explore the influence of lenticulostriate artery on quantitative perfusion of basal ganglia brain tissue and predict the prognosis of patients[J]. Journal of Capital Medical University, 2022, 43(1): 53-60.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.01.011

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I1/53

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