Journal of Capital Medical University ›› 2022, Vol. 43 ›› Issue (2): 167-172.doi: 10.3969/j.issn.1006-7795.2022.02.001

• Basic and Clinical Research on Cardiology •     Next Articles

Correlation analysis of soluble advanced glycation end product receptors and renal function in patients with coronary atherosclerotic heart disease

Chen Lu1, Guo Xinying1, Liu Jian1, Du Fenghe2, Guo Caixia1*   

  1. 1. Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
    2. Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2021-12-23 Online:2022-04-21 Published:2022-04-14
  • Contact: *E-mail:cxgbb@163.com
  • Supported by:
    National Natural Science Foundation of China (82171080, 81870265), China Young and Middle-aged Clinical Research Fund (2017-CCA-VG-045).

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Abstract: Objective To evaluate the correlation between soluble receptor for advanced glycation end products (sRAGE) and renal function in patients with coronary atherosclerotic heart disease (CHD). Methods This study was a cross-sectional study. Plasma sRAGE and renal function indexes were detected in patients diagnosed with CHD who underwent coronary angiography in hospital. According to estimated glomerular filtration rate (eGFR), patients were divided into normal renal function group and decreased renal function group. Clinical characteristics and sRAGE levels of the two groups were compared, and the correlation between plasma sRAGE levels and renal function was analyzed by Spearman correlation and Logistic regression. Results A total of 170 patients were enrolled in the study. Correlation analysis showed that sRAGE was positively correlated to creatinine (r=0.152, P=0.048) and blood urea nitrogen (r=0.160, P=0.038), but negatively correlated to eGFR (r=-0.185, P=0.016). There were 109 patients in normal renal function group and 61 patients in decreased renal function group. Compared with the normal renal function group, sRAGE level was increased [(2.00±0.61) μg/L vs (1.70±0.60) μg/L, P=0.003] in the decreased renal function group.Multivariate Logistic regression analysis showed that sRAGE was correlated to decreased renal function in patients with CHD (OR=2.954, 95%CI: 1.030-8.474, P=0.044). Conclusion Plasma sRAGE might be a potential indicator for decreased renal function in CHD patients.

Key words: soluble receptor for advanced glycation end products, coronary heart atherosclerotic disease, renal function

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