Chromosomal analysis in 134 cases of fetuses with growth restriction

doi:10.3969/j.issn.1006-7795.2022.03.008

Abstract

Abstract: Objective To explore the chromosomal analysis for fetuses with fetal growth restriction (FGR). Methods This was a retrospective study on 134 pregnancies with fetal growth restriction which underwent prenatal diagnosis,including amniotic fluid, cordocentesis, or fetal tissue after abortion. The kayotype and copy number variations (CNVs) were performed by G320-banding and copy number variation sequencing, and the indication of the procedures and results were evaluated. Results Among 134 cases with indication of fetal growth restriction, 13 (9.7%, 13/134) cases were diagnosed with chromosome abnormities,including nine cases with pathogenic CNVs. There were 3 cases with chromosomal abnormalities in 41 cases with isolated FGR (3/41, 7.3%), the incidence was lower than that with syndromic FGR (10/93, 10.8%), but no significant difference between two groups (P=0.762). Conclusion The incidence of chromosomal abnormalities in fetus with FGR was higher and prenatal diagnosis is recommended for all types of the disease. It is recommended to place a priority on CNVs in prenatal diagnosis.”

Key words: fetal growth restriction, prenatal diagnosis, gene copy number variations, chromosomal abnormality

CLC Number:

R715.7

Hou Lei, Wang Xiaoxin, Liu Liheng, Zhang Weiyuan, Wang Xin. Chromosomal analysis in 134 cases of fetuses with growth restriction[J]. Journal of Capital Medical University, 2022, 43(3): 375-379.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.03.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I3/375

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