Relationship between mild cognitive impairment and menopausal symptoms in Chinese women

doi:10.3969/j.issn.1006-7795.2022.03.007

Abstract

Abstract: Objective To investigate the relationship between mild cognitive impairment (MCI) and various typical menopausal symptoms in Chinese women. Methods A total of 150 volunteers were included in the study,and there were 61 cases(40.7%) in MCI group and 89 cases (59.3%) in non-MCI group. Montreal Cognitive Assessment (MoCA) was used to assess cognitive function. Clinical, sociodemographic and anthropometric data were collected, and menopausal symptoms were evaluated by Modified Kupperman Index (KMI). The two groups were compared by t-test and χ² inspection. Binary Logistic regression model was used to predict the risk factors of mild cognitive impairment. Results Univariate analysis showed that there were significant differences in age (P=0.001), education level (P=0.001), KMI score (P<0.001) and insomnia (P=0.033) between the two groups. Multivariate analysis found that, insomnia (P=0.032) and headache (P=0.021) were independent risk factors, while education (P=0.004) was independent protective risk factor for MCI in patients under 55 years. Conclusion We reported a clear association between various menopausal symptoms and MCI. This may provide novel direction for the prevention of dementia.

Key words: mild cognitive impairment, menopause, Modified Kupperman Index, Montreal Cognitive Assessment, menopausal symptoms

CLC Number:

Xu Xin, Ruan Xiangyan, Ju Rui, Yang Yu, Cheng Jiaojiao, Wang Zhikun, Alfred O. Mueck. Relationship between mild cognitive impairment and menopausal symptoms in Chinese women[J]. Journal of Capital Medical University, 2022, 43(3): 369-374.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.03.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I3/369

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