Research advances in the anti-inflammatory effects and mechanisms of baicalin in chronic inflammatory diseases of respiratory mucosa

doi:10.3969/j.issn.1006-7795.2022.06.016

Abstract

Abstract: Baicalin is a kind of flavonoid component derived from the root of Scutellaria baicalensis, the main active ingredient of the plant. It has a wide range of pharmacological effects such as anti-inflammatory, anti-cancer, antiviral and antioxidant effects.Chronic inflammatory diseases of the respiratory mucosa, mainly chronic rhinosinusitis, allergic rhinitis and asthma, are among the serious chronic diseases affecting human daily life. The pathogenesis is complex and the current therapeutic methods have certain limitations and adverse effects.The traditional Chinese medicine baicalin has the potential to be developed as a drug for the treatment of chronic inflammatory diseases of the respiratory mucosa because of its good anti-inflammatory effect and low toxic side effects.In this review, we summarize the anti-inflammatory mechanism of baicalin in chronic inflammatory diseases of the respiratory mucosa and provide theoretical basis for its clinical application in related diseases.

Key words: baicalin, chronic inflammation of respiratory mucosa, anti-inflammatory effect, research advances

CLC Number:

R765

Yang Jingxing, Cai Chao, Zhao Yan, Wang Xiangdong, Zhang Luo. Research advances in the anti-inflammatory effects and mechanisms of baicalin in chronic inflammatory diseases of respiratory mucosa[J]. Journal of Capital Medical University, 2022, 43(6): 919-923.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.06.016

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I6/919

References

[1] Bousquet J, Anto J M, Bachert C, et al. Allergic rhinitis[J]. Nat Rev Dis Primers, 2020, 6(1): 95.
[2] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 中国变应性鼻炎诊断和治疗指南(2022年,修订版)[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(2): 106－129.
[3] Fokkens W J, Lund V J, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(Suppl S29): 1－464.
[4] Schleimer R P. Immunopathogenesis of chronic rhinosinusitis and nasal polyposis[J]. Annu Rev Pathol, 2017, 12: 331－357.
[5] 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2020年版)[J]. 中华结核和呼吸杂志, 2020, 43(12): 1023－1048.
[6] Anushiravani M, Bakhshaee M, Taghipour A, et al. A systematic review of randomized controlled trials with herbal medicine on chronic rhinosinusitis[J]. Phytother Res, 2018, 32(3): 395－401.
[7] Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin[J]. Cancer Treat Rev, 2009, 35(1): 57－68.
[8] Zhao Q, Chen X Y, Martin C. Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants[J]. Sci Bull (Beijing), 2016, 61(18): 1391－1398.
[9] Liu W, Wang H L, Zhu B, et al. An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae[J]. PLoS One, 2017, 12(5): e0175751.
[10] Donald G, Hertzer K, Eibl G. Baicalein—an intriguing therapeutic phytochemical in pancreatic cancer[J]. Curr Drug Targets, 2012, 13(14): 1772－1776.
[11] Dinda B, Dinda S, DasSharma S, et al. Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders[J]. Eur J Med Chem, 2017, 131: 68－80.
[12] 潘刚强, 袁岳沙, 陈杰, 等. Th1/Th2细胞因子在过敏性鼻炎患者表达水平研究[J]. 检验医学与临床, 2010, 7(22): 2472－2473.
[13] 黄丰, 童晓云, 邓华明, 等. 黄芩苷调节哮喘模型小鼠Th1/th2反应机制初探[J]. 中药材, 2009, 32(9): 1407－1410.
[14] Bui T T, Piao C H, Song C H, et al. Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release[J]. Anat Cell Biol, 2017, 50(2): 124－134.
[15] Ma C H, Ma Z Q, Fu Q, et al. Anti-asthmatic effects of baicalin in a mouse model of allergic asthma[J]. Phytother Res, 2014, 28(2): 231－237.
[16] Huang X K, Chen Y L, Zhang F C, et al. Peripheral th17/treg cell-mediated immunity imbalance in allergic rhinitis patients[J]. Braz J Otorhinolaryngol, 2014, 80(2): 152－155.
[17] 王娅, 王悦, 马永明, 等. Th9和Th17及Treg细胞在鼻息肉发病中的研究与探讨[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(4): 1001－1781.
[18] 武大伟, 宋倩. Th17/Treg细胞失衡在嗜酸粒细胞性慢性鼻-鼻窦炎伴鼻息肉黏膜重塑中的作用[J]. 临床耳鼻咽喉头颈外科杂志, 2014, 28(20): 1001－1781.
[19] Zou X L, Chen Z G, Zhang T T, et al. Th17/Treg homeostasis, but not Th1/Th2 homeostasis, is implicated in exacerbation of human bronchial asthma[J]. Ther Clin Risk Manag, 2018, 14: 1627－1636.
[20] 谭倩, 刘志丹, 李晓燕, 等. Th17/Treg细胞失衡在变应性鼻炎中的作用研究进展[J]. 中国免疫学杂志, 2017, 33(4): 638－642.
[21] Li J, Li Y. Autophagy is involved in allergic rhinitis by inducing airway remodeling[J]. Int Forum Allergy Rhinol, 2019, 9(11): 1346－1351.
[22] Li J, Lin X Y, Liu X, et al. Baicalin regulates Treg/Th17 cell imbalance by inhibiting autophagy in allergic rhinitis[J]. Mol Immunol, 2020, 125: 162－171.
[23] Yang M, Zhu X Y, Fu F D, et al. Baicalin ameliorates inflammatory response in a mouse model of rhinosinusitis via regulating the Treg/Th17 balance[J]. Ear Nose Throat J, 2022, 101(2_suppl): 8S－16S.
[24] 王平. 黄芩苷对过敏性哮喘小鼠Th17/Treg反应失衡的调节作用研究[D]. 延吉: 延边大学, 2016.
[25] Tak P P, Firestein G S. NF-κB: a key role in inflammatory diseases[J]. J Clin Invest, 2001, 107(1): 7－11.
[26] Xu R, Xu G, Shi J, et al. A correlative study of NF-κB activity and cytokines expression in human chronic nasal sinusitis[J]. J Laryngol Otol, 2007, 121(7): 644－649.
[27] Höpken U E, Foss H D, Meyer D, et al. Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs[J]. Blood, 2002, 99(4): 1109－1116.
[28] Liu J Q, Wei Y, Luo Q L, et al. Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21[J]. Int J Mol Med, 2016, 38(5): 1541－1548.
[29] Hsieh C J, Hall K, Ha T Z, et al. Baicalein inhibits IL-1β-and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway[J]. Clin Mol Allergy, 2007, 5(1): 5.
[30] Stevens W W, Kato A. Group 2 innate lymphoid cells in nasal polyposis[J]. Ann Allergy Asthma Immunol, 2021, 126(2): 110－117.
[31] Poposki J A, Klingler A I, Tan B K, et al. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps[J]. Immun Inflamm Dis, 2017, 5(3): 233－243.
[32] Yoshida K, Takabayashi T, Kaneko A, et al. Baicalin suppresses type 2 immunity through breaking off the interplay between mast cell and airway epithelial cell[J]. J Ethnopharmacol, 2021, 267: 113492.
[33] Chen S Z, Chen G R, Shu S, et al. Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats[J]. R Soc Open Sci, 2019, 6(2): 181081.