ffect of intraoperative oxygen concentration on postoperative neurological function and complications in patients undergoing cerebrovascular recanalization

doi:10.3969/j.issn.1006-7795.2023.05.023

Abstract

Abstract: Objective To investigate the safety and efficacy of intraoperative normobaric hyperoxia as an auxiliary neuroprotective strategy combined with endovascular recanalization in the treatment of patients with ischemic cerebrovascular disease (ICVD). Methods This is a single-center retrospective cohort study, including patients aged 60 and older with ICVD and operation duration≥2 h in Beijing Tiantan Hospital, Capital Medical University from January 2016 to September 2021 and received endovascular recanalization under general anesthesia. A total of 351 patients were divided into H group (100% O2, 109 cases) and L group (50% O2, 242 cases) according to the intraoperative inhaled oxygen concentration. The National Institute of Health Stroke Scale （NIHSS) score was used to evaluate the degree of neurological deficit in stroke patients. Modified Rankin Scale （mRS） score was applied to evaluated the recovery status of neurological function in patients after stroke. We also compared the differences of NIHSS score and mRS score after operation and discharge, and postoperative complications (pneumonia, re-stroke, cerebral hemorrhage) between the two groups. Spearman correlation analysis was used to explore the correlation factors with NIHSS score. Results There was no significant difference in the postoperative and discharge NIHSS score, mRS score and postoperative complication rate between the two groups (P>0.05). Compared to H group, the hospital stay in L group was significantly shorter (P<0.05). The relevant factor for postoperative NIHSS score were oxygen concentration, emergency, preoperative stenosis rate, stenosis length, hyperlipidemia, preoperative NIHSS score and preoperative mRS score. Conclusion Although normobaric hyperoxia has limited effect as an adjuvant neuroprotective strategy based on vascular recanalization in patients with ICVD, it has no significant effect on the recent neurological recovery of patients, but it does not increase the incidence of postoperative complications.

Key words: normobaric hyperoxia, ischemic cerebrovascular disease, National Institute of Health Stroke Scale（NIHSS） score, modified Rankin Scale(mRS) score

CLC Number:

R614
R743

Hu Zhengfang, Wang Juan, Jian Minyu, Han Ruquan. ffect of intraoperative oxygen concentration on postoperative neurological function and complications in patients undergoing cerebrovascular recanalization[J]. Journal of Capital Medical University, 2023, 44(5): 865-871.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.05.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I5/865

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