Abstract: Objective To evaluate the clinical effects of minocycline ointment (Perioline) supplementary treatment on periodontitis resulted from fixed partial dentures.Methods 32 patients with periodontitis resulted from fixed partial dentures were enrolled in the study.Following supragingival scaling and subgingival scaling the patients were randomly divided into test group (80 sites) and control group (88 sits). The periodontal pockets were administered with either minocycline ointment in test group or saline solution in control group at baseline, week 2, week 3, and week 4.Clinical stores of plaque index (PLI), bleeding on probing (BOP), and probing depth (PD) were analyzed at baseline, week 4 and week 8.Results Both therapies resulted in significant improvements compared with baseline in terms of PLI, BOP and PD scores. Statistically significant differences were noted between the two groups, which suggested that the test group was superior to the control group.Conclusion Local administration of minocycline ointment (Perioline) in the treatment of periodontitis resulted from fixed partial dentures is safe and results in significant clinical improvement after supragingival and subgingival instrumentation.

Key words: minocycline, periodontitis, fixed partial dentures, periodontal pocket