Journal of Capital Medical University ›› 2025, Vol. 46 ›› Issue (5): 866-876.doi: 10.3969/j.issn.1006-7795.2025.05.016

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Effect of liraglutide on renal function and proteinuria level in patients with type 2 diabetes mellitus: a Meta-analysis

Feng Yiduo, Zhou Yilun*   

  1. Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2025-01-23 Revised:2025-03-06 Online:2025-10-21 Published:2025-10-22
  • Supported by:
    This study was supported by Beijing Municipal Administration of HospitalsAscent Plan (DEL20190502).

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Abstract: Objective  This study aimed to explore the effect of liraglutide on estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) levels in patients with type 2 diabetes mellitus (T2DM). Methods  Databases including PubMed, Embase, Cochrane Library, WanFang, and China National Knowledge Infrastructure (CNKI) were systematically searched from inception to June 30, 2024. According to the inclusion criteria, randomized controlled trials (RCTs) involving intervention of liraglutide in T2DM were identified. Parameters of eGFR and UACR were extracted pre- and post-treatment in each study. A fixed or random-effects model was used for quantitative synthesis according to the heterogeneity, which was assessed with I2 index.  Quality of eligible RCTs was evaluated based on the Cochrane criteria. Sensitivity test was conducted by using the standard method. Publication bias was evaluated according the Begg’s and Egger’s tests. Meta-analysis was performed with Revman 5.3 and Stata 12.0 softwares.  Results  A total of 10 studies, which included 11 RCTs and involved 657 patients, were ultimately identified after performing a systematic search. Of these, 322 patients were administered with liraglutide. The overall quality of eligible RCTs was rated as medium. Compared with control group, no significant changes of eGFR (WMD=4.52  mL/min/1.73 m2，95% CI: -2.79-11.84，I2=88%，P =0.23) was observed in liraglutide-treated participants. In contrast, liraglutide significantly improved levels of UACR (WMD=-13.48 mg/g，95% CI: -22.68 - -4.29，I2 =75%，P =0.004）. The results were stable according to the sensitivity test. No significant publication bias was demonstrated after performing the Begg’s and Egger’s tests. Conclusions  The administration of liraglutide prevented the decline of eGFR and reduced UACR in T2DM. These results suggested that diabetic participants potentially benefit more from liraglutide treatment in clinical practice.

Key words: liraglutide, type 2 diabetes mellitus, estimated glomerular filtration rate, urine albumin-to-creatinine ratio, glucagon-like peptide-1 receptor agonists, Meta-analysis

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