Efficacy and Safety Octreotide in the Treatment of Acute Variceal Bleeding in Cirrhotic Patients

Abstract

Abstract: Objective To investigate the efficacy and safety of octreotide acetate and sandostatin in controlling esophageal variceal bleeding,and make comparison between domastic and imported products.Methods One hundred and thirty-one cirrhotic patients with esophageal and gastric variceal bleeding were divided into two groups randomly.68 cases in Group A were treated with octreotide acetate infusion.63 cases in Group B were treated with sandostatin infusion.Group A received octreotide acetate infusion of 50 μg/h intravenously for 120 h after a bolus of 100 μg.Group B same dose sandostatin in same way.The blood pressure,arterial pulse and blood transfusion volume were monitored and recorded in the course of the investigation.Results The base-line data in the two groups were similar.The efficacy of octreotide in hemostasis,the blood transfusion volume and mortality have no significant difference between two groups in statistically(P>0.05).Conclusion Both octreotide and sandostatin present a high initial and final control of esophageal and gastric variceal bleeding.

Key words: octreotide, esophageal and gastric varices, bleeding, therapy

CLC Number:

R575.2⁺1

Yang Xun;Li Hongmei;Yu Zhonglin;Zhang Shutian. Efficacy and Safety Octreotide in the Treatment of Acute Variceal Bleeding in Cirrhotic Patients[J]. Journal of Capital Medical University, 2006, 27(4): 457-459.

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Efficacy and Safety Octreotide in the Treatment of Acute Variceal Bleeding in Cirrhotic Patients

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