Abstract: Objective To improve the understanding of AIDS-associated Penicilliosis marneffei(PSM).Methods Study the clinical data and imaging feature of four cases with PSM infection in patients with AIDS in Beijing You'an hospital.Results Four patients presented with prolonged fever,cough,lymphaden hypertrophy,abdominal pain,diarrhea,hepatomegaly,splenomegaly and popular skin lesion.CD₄ cell count was reduced significantly.Two cases chest X-ray showed interstitial or alveolar pneumonia,Abdominal CT showed multiple abcess in peritoneal cavity and organs.Chest CT showed the patchy or consolidation,military nodules in the lung,lymphadenhy pertrophy in hilar and mediastasis.Fungus cultured:yeast-like cells were found in the culture at 37℃ or in tissues.The fungi outside the host cells were elongated,often curved,Sausage-like and with clear cemral septate.When cultured at 25℃,the produced a characteristic red Pigment,diffusing into the medium.Conclusion PSM infection in patients with AIDS has not specific clinical manifestation.Clinical doctors should consider the possibility of PSM when the patients have the above mentioned symptoms.Culture and pathological examination should be taken as soon as possible.It is important for the successful management and treatment of AIDS-associated PSM to make diagnosis rapidly and accurately.

Key words: acquired immunodeficiency syndrome, mycoses, penicillium