Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (3): 321-324.

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Evaluation of Cytocompatibility of Several Biomaterials on Vascular Tissue Engineering

Lu Guang, Zhang Jian, Li Jianxin, Gu Yongquan, Sun Haichen, Chen Liang, Liu Qingyang, Wang Zhonggao   

  1. Department of Vascular Surgery,Xuanwu Hospital, Capital University of Medical Sciences; The Institute of Vascular Surgical Research, Capital University of Medical Sciences
  • Received:2005-10-29 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24

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Abstract:

Objective To study the cytocompatibility of several biomaterials such as polyhydroxybutyrate-polyhydroxyvalerate(PHBV) with human fibroblast cell and provide the better materials for vascular tissue engineering.Methods The fibroblast cell were cultured on the surface of several biomaterials in vitro, then the morphological characters were observed with fluorescence microscope and cell proliferation were detected with MTT assay. In addition, the biomaterials contact angle were measured.Results In all biomaterials, PHBV's contact angle was the smallest and it's cytocompatibility is the best.Conclusion PHBV has good cytocompatibility and could be the better biomaterial for the vascular tissue engineering.

Key words: biomaterials, cytocompatibility, tissue engineering blood vessel, fluorescence staining

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