Serum Levels of VEGF,VEGF C and uPAR in Patients withOral Squamous Cell Carcinoma

Journal of Capital Medical University ›› 2007, Vol. 28 ›› Issue (2): 158-161.

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Serum Levels of VEGF,VEGF C and uPAR in Patients withOral Squamous Cell Carcinoma

Yu Xuemei¹, Liu Xiaoyong¹, Wang Yajie², Ding Li¹

1. Department of Oral Pathology, Beijing Stomatology Hospital, Capital Medical University;2. Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University

Received:2007-01-16 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24

Abstract

Abstract:

Objective The serum levels of VEGF, VEGF C and uPAR in patients with oral squamous cell carcinoma(OSCC) were determined to study the relationship between VEGF, VEGF C and uPAR serum levels and pathological parameters or lymphatic metastasis in OSCC. Methods Serum levels of VEGF, VEGF C and uPAR were measured with quantitative enzyme-linked immunosorbent assay in 91 patients with OSCC and in 50 healthy individuals as control group. Results Significantly elevated levels of VEGF, VEGF C and uPAR were observed in OSCC compared with control group. No statistically significant correlation could be found between the serum levels and histological grading, infiltrative mode or nodal status in OSCC. Conclusion Serum determinations of VEGF, VEGF C and uPAR may provide laboratory data for monitoring the occurrence and development of OSCC, but have no significance in predicting lymphatic metastasis.

Key words: oral squamous cell carcinoma, VEGF, VEGF C, uPAR

CLC Number:

R739.81

Yu Xuemei;Liu Xiaoyong;Wang Yajie;Ding Li. Serum Levels of VEGF,VEGF C and uPAR in Patients withOral Squamous Cell Carcinoma[J]. Journal of Capital Medical University, 2007, 28(2): 158-161.

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Serum Levels of VEGF,VEGF C and uPAR in Patients withOral Squamous Cell Carcinoma

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