血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析

doi:10.3969/j.issn.1006-7795.2015.02.022

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (2): 287-290.doi: 10.3969/j.issn.1006-7795.2015.02.022

血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析

高新晓¹, 郭佳¹, 蔺洁², 孟忻¹, 汪军¹

1. 首都医科大学附属北京安贞医院眼科, 北京 10029;
2. 首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所动脉粥样硬化研究室, 北京 10029

收稿日期:2014-12-15 发布日期:2015-04-16
通讯作者: 汪军 E-mail:junmaster@live.cn
基金资助:
国家自然科学基金(81370443,81170793),中华医学会临床医学科研专项资金项目(14010110548),首都医科大学附属北京安贞医院院长科技发展基金种子基金(2013Z02)。

Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids

Gao Xinxiao¹, Guo Jia¹, Lin Jie², Meng Xin¹, Wang Jun¹

1. Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;
2. The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China

Received:2014-12-15 Published:2015-04-16
Supported by:
This study was supported by National Natural Sciences Foundation of China(81370443, 81170793), Clinical Research Foundation from Chinese Medical Association(14010110548), Seed Project of Technical Development Foundation from Capital Medical University Affiliated Beijing Anzhen Hospital(2013Z02).

摘要/Abstract

摘要：

目的精确检测低密度脂蛋白(low density lipoprotein,LDL)的亚组分并评估其中的小而密低密度脂蛋白(small dense LDL,sdLDL)与青年角膜弓(简称青年弓)的相关性。方法入选12例2014年3月至2014年10月就诊于首都医科大学附属北京安贞医院眼科及体检中心的血脂正常的青年弓患者。另外选取12例年龄、性别、吸烟史相匹配的健康对照者。采用Lipoprint LDL System精确检测LDL的亚组分,计算其中的sdLDL占LDL的百分数,即sdLDL比率(sdLDL%)。采用t检验比较青年弓组与对照组的sdLDL%,再以青年弓为因变量,通过Logistic回归分析(Backward:LR)评估其相关因素。结果与对照组相比,青年弓组sdLDL%数值偏高[(13.16±6.29)% vs (19.64±6.52)%],差异有统计学意义(P=0.020)。Logistic回归分析显示:将年龄、LDL校正后,sdLDL%增高和青年弓明显相关(P=0.040)。sdLDL%是青年弓发生的危险因素(OR=1.49,95% CI:1.01~2.19,P<0.05)。结论血脂正常青年弓患者的sdLDL%增高,表明其LDL亚组分异常。

关键词: 青年角膜弓, Lipoprint LDL System, 小而密低密度脂蛋白

Abstract:

Objective To exactly analyze low density lipoprotein(LDL) subclass and examine the association between small dense LDL(sdLDL) and corneal arcus in young patients. Methods We selected 12 cases of young patients with corneal arcus and normal serum lipids. Another 12 control cases with matched age, gender, smoking were recruited from Beijing Anzhen Hospital between March 2014 and October 2014. LDL particle separation was performed by Lipoprint System: LDL subfractions were obtained and sdLDL proportion(% of sdLDL particles) was calculated. sdLDL% was compared with the Student t test between two groups. Logistic regression analysis was performed to evaluate the correlation between corneal arcus and its related factors. Results SdLDL% was increased in corneal arcus group compared with controls[(19.64±6.52)% vs (13.16±6.29)%]. The difference between the two groups was significant(P=0.020). SdLDL% was significantly associated with corneal arcus(P=0.040) after controlling for age and LDL. SdLDL% played a role in the development of corneal arcus(OR=1.49, 95% CI: 1.01-2.19, P<0.05). Conclusion These findings suggested that young patients with corneal arcus and normal serum lipids had increased level of sdLDL proportion, indicating the abnormality of LDL subclass in such cases.

Key words: corneal arcus, Lipoprint LDL System, small dense low density lipoprotein

中图分类号:

R446

高新晓, 郭佳, 蔺洁, 孟忻, 汪军. 血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析[J]. 首都医科大学学报, 2015, 36(2): 287-290.

Gao Xinxiao, Guo Jia, Lin Jie, Meng Xin, Wang Jun. Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids[J]. Journal of Capital Medical University, 2015, 36(2): 287-290.

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参考文献

[1] Christoffersen M, Frikke-Schmidt R, Schnohr P, et al. Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population:prospective cohort study[J]. BMJ, 2011,343:d5497.
[2] Wu R, Wang J J, Tai E S, et al. Cardiovascular risk factors, inflammation, and corneal arcus:the singapore malay eye study[J]. Am J Ophthalmol, 2010,150(4):581-587.
[3] Crispin S. Ocular lipid deposition and hyperlipoproteinaemia[J]. Prog Retin Eye Res, 2002,21(2):169-224.
[4] Newell F W. The Cornea[M]. 8th ed. St. Louis:CV Mosby Co., 1986.
[5] Austin M A, Breslow J L, Hennekens C H, et al. Low-density lipoprotein subclass patterns and risk of myocardial infarction[J]. JAMA, 1988,260(13):1917-1921.
[6] Chapman M J, Guérin M, Bruckert E. Atherogenic, dense low-density lipoproteins. Pathophysiology and new therapeutic approaches[J]. Eur Heart J, 1998,19(Suppl A):A24-A30.
[7] Berneis K K, Krauss R M. Metabolic origins and clinical significance of LDL heterogeneity[J]. J Lipid Res, 2002,43(9):1363-1379.
[8] Moon J Y, Kwon H M, Kwon S W, et al. Lipoprotein(a) and LDL particle size are related to the severity of coronary artery disease[J]. Cardiology, 2007,108(4):282-289.
[9] Kullo I J, Ballantyne C M. Conditional risk factors for atherosclerosis[J]. Mayo Clin Proc, 2005,80(2):219-230.
[10] Pauciullo P, Gentile M, Marotta G, et al. Small dense low-density lipoprotein in familial combined hyperlipidemia:independent of metabolic syndrome and related to history of cardiovascular events[J]. Atherosclerosis, 2009,203(1):320-324.
[11] Lagos K G, Filippatos T D, Tsimihodimos V, et al. Alteration in the high density lipoprotein phenotype and HDL associated enzymes in subjects with metabolic syndrome[J]. Lipids, 2009,44(1):9-16.
[12] Mora S, Otvos J D, Rosenson R S, et al. Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women[J]. Diabetes, 2010,59(5):1153-1160.
[13] Fernández A, Sorokin A, Thompson PD. Corneal arcus as coronary artery disease risk factor[J]. Atherosclerosis, 2007,193(2):235-240.
[14] 孟忻,蔺洁,辛晨,等.杂合型家族性高胆固醇血症的角膜青年环一例[J].眼科,2012,21(2):105-106.
[15] Meng X, Lin J, Gao X, et al. Corneal arcus and xanthomas in homozygous familial hypercholesterolemia:first report from China[J]. Indian J Ophthalmol, 2013;61(12):770-771.
[16] Krauss R M. Dense low density lipoproteins and coronary artery disease[J]. Am J Cardiol, 1995,75(6):53B-57B.
[17] Fernandez A B, Keyes M J, Pencina M, et al. Relation of corneal arcus to cardiovascular disease[J]. Am J Cardiol, 2009,103(1):64-66.
[18] Zech L A Jr, Hoeg J M. Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia[J]. Lipids Health Dis, 2008,7:7.
[19] Ang M, Wong W, Park J, et al. Corneal arcus is a sign of cardiovascular disease, even in low-risk persons[J]. Am J Ophthalmol, 2011,152(5):864-871.

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血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析

Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids

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